Assessment of the efficacy and safety of favipiravir in patients with SARS-CoV-2 infection in United Arab Emirates: A single-center study

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Bayan Ayash
Sahab Alkhoujah
Neena Abraham
Ahmad El Ouweini
Sara Mansour
Syed Wassif Gillani
Rabih Hallit
Souheil Hallit
Diana Malaeb


COVID-19, favipiravir, symptomatic management, safety, efficacy


Background: Anti-viral medications are among the treatment options for coronavirus infectious disease 2019 (COVID-19) management although they are still not FDA approved for coronavirus treatment. We conducted the study to assess the efficacy, and safety of favipiravir versus symptomatic management in patients with COVID-19. Methods: A cross-sectional study included 476 participants, divided into two groups. All patients received symptomatic management, and 300 received favipiravir 1,600 mg/day on day 1 and 600 mg/day on days 2 to 5. Results: The mean age of the patients was 44.18 ± 12.24 years (49.2% females). The most described COVID-19 symptoms was cough, followed by sore throat, headache, and fever. Each side effect of favipiravir was experienced by almost 38% of the patients. The average days for symptoms relief was 4.73 ± 2.25 days. The results of the linear regression showed that the intake of favipiravir vs symptomatic management only was significantly associated with a higher mean number of days until symptoms relief. Conclusion: The results highlight that efficacy of favipiravir is not supported yet for the treatment of COVID-19 as it was associated with higher mean number of days until symptoms relief. However, no remarkable issues with safety associated with Favipiravir were observed.

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