Point prevalence survey of antibiotic utilization in secondary care hospital in the United Arab Emirates

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Prevalence survey, Antibiotic, Prescribing, Hospital, Secondary care, UAE


Objectives: The present study was carried out to identify and report the pattern of antibiotics prescribing to determine the adherence to the international empirical and therapeutic guidelines of antibiotic use. Methods: A point prevalence survey took place at a selected date of January 26, 2020, in which data collection was performed to all the patients present in the hospital who used at least one systemic antibiotic agent as an inpatient from 00:00 am until midnight of that day. This was performed using European Surveillance of Antimicrobial Consumption (ESAC – audit tool). The participated hospital in this point prevalence study represents a major government hospital in the UAE. Descriptive statistics were used and results were expressed using standard statistical methods. Results: Out of the 125 hospitalized patients, a total of 41 (32.8%) patients were included in the survey and treated with different trends of antibiotics on the date point prevalence survey. The total number prescribed antibiotics was 54 with a higher percentage of treatment indication (70.4%), compared to prophylaxis indication (29.6%). The combinations of penicillin’s win in being the most commonly used agents by a percent of 31.5%, including the use of Amoxicillin-clavulanic acid by 22.2% and Piperacillin-tazobactam with 9.3%. The compliance with local/international guidelines accounts for 78.0% of the treated & prophylaxis patients. Conclusions: Considerable results have been obtained which can assure the quality improvement of the antibiotic use in the studied hospital.

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1. Alahmadi Y, Aldeyab M, Scott M. Point-prevalence surveys of antibiotic use and HAIs. Hospital Pharmacy Europe Pharmacy practice). 2016;84:27-29.
2. Vernaz NC, Huttner B, Muscionico D. Modelling the impact of antibiotic use on antibiotic-resistant Escherichia coli usingpopulation-bases data from a large hospital and its surrounding community. J Antimicrob Chemother. 2011;66(4):928-935. https://doi.org/10.1093/jac/dkq525
3. Hao H, Dai M, Wang Y, et al. Key genetic elements and regulation systems in methicillin-resistant Staphylococcus aureus.Future Microbiol. 2012;7(11):1315-1329. https://doi.org/10.2217/fmb.12.107
4. Aldeyab MA, Scott MG, Kearney M. Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings. Epidemiol Infect. 2014;142(3):494-497. https://doi.org/10.1017/S0950268813001374
5. Self WH, Wunderink RG, Williams DJ. Staphylococcus aureus Community-acquired Pneumonia: Prevalence, Clinical Characteristics, and Outcomes. Clin Infect Dis. 2016;63(3):300-310.
6. Ledda A, Price JR, Cole K. Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus. J Antimicrob Chemother. 2017;72(5):1285-1284. https://doi.org/10.1093/jac/dkw570 
7. Thompson I. Clostridium difficile-associated disease: update and focus on non-antibiotic strategies. Age Ageing. 2008;37(1):14-8. https://doi.org/10.1093/ageing/afm159 
8. Planche T. Clostridium difficile. Prevention and Control of Infection. 2013;41:654-655.
9. Al Matar M, Enani M, Binsaleh G. Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016. J Infect Public Health.2019;12(1):77-82. https://doi.org/10.1016/j.jiph.2018.09.003
10. Pakyz AL, MacDougall C, Oinonen M. Trends in antibacterial use in US academic health centers: 2002 to 2006. Arch Intern Med.2008;168(20):2254-2260. https://doi.org/10.1001/archinte.168.20.2254
11. Hulscher ME, van der Meer JW, Grol RP. Antibiotic use: how to improve it? Int J Med Microbiol. 2010;300(6):351-356. https://doi.org/10.1016/j.ijmm.2010.04.003
12. Almomani BA, Khasawneh RA, Saqan R. Predictive utility of prior positive urine culture of extended- spectrum β -lactamase producing strains. PLoS One. 2020;15(12):e0243741. https://doi.org/10.1371/journal.pone.0243741
13. Robert J, Péan Y, Varon E, et al. Surveillance de la prescription des antibiotiques (SPA) Group. Point prevalence survey of antibiotic use in French hospitals in 2009. J Antimicrob Chemother. 2012;67(4):1020-1026. 10.1093/jac/dkr571
14. Infectious Diseases Society of America (IDSA), Spellberg B, Blaser M, Guidos RJ. Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis. 2011;52(Suppl 5):S397-428. https://doi.org/10.1093/cid/cir153
15. Stichele RHV, Elseviers MM, Ferech M. European surveillance of antimicrobial consumption (ESAC): data collection performance and methodological approach. Br J Clin Pharmacol. 2004;58(4):419-428. https://doi.org/10.1111/j.1365-2125.2004.02164.x
16. Dumpis U, Balode A, Vigante D. Prevalence of nosocomial infections in two Latvian hospitals. Euro Surveill. 2003;8(3):73-78.https://doi.org/10.2807/esm.08.03.00405-en
17. MacDougall C, Polk RE. Antimicrobial stewardship programs in health care systems. Clin Microbiol Rev. 2005;18(4):638-656.https://doi.org/10.1128/CMR.18.4.638-656.2005
18. Aldeyab MA, Kearney MP, McElnay JC, et al. A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool. Epidemiol Infect. 2012;140(9):1714-1720. https://doi.org/10.1017/S095026881100241X
19. Zarb P, Amadeo B, Muller A. Hospital Care Subproject Group. Identification of targets for quality improvement in antimicrobial prescribing: the web-based ESAC Point Prevalence Survey 2009. J Antimicrob Chemother. 2011;66(2):443-449. https://doi.org/10.1093/jac/dkq430
20. W H O. The 2019 WHO AWaRe classification of antibiotics for evaluation and monitoring of use. Geneva: World Health Organization; 2019. https://apps.who.int/iris/handle/10665/327957
21. Usluer G, Ozgunes I, Leblebicioglu H. Turkish Antibiotic Utilization Study Group. A multicenter point-prevalence study:antimicrobial prescription frequencies in hospitalized patients in Turkey. Ann Clin Microbiol Antimicrob. 2005;4:16. https://doi.org/10.1186/1476-0711-4-16
22. Hu S, Liu X, Peng Y. Assessment of antibiotic prescription in hospitalised patients at a Chinese university hospital. J Infection.2003;46(3):161-164. https://doi.org/10.1053/jinf.2002.1078
23. National Institute for Health and Clinical Excellence (NICE). Surgical site infection. NICE guideline. Draft for consultation. 2008.https://www.nice.org.uk/guidance
24. Alnajjar MS, Alashker DA. Surgical site infections following caesarean sections at Emirati teaching hospital: Incidence and implicated factors. Sci Rep. 2020;10(1):18702. https://doi.org/10.1038/s41598-020-75582-9