Conservation of Medicinal plants by sustainable aquaponics approach for novel drug development

Main Article Content

Ramya Manoharan
Chythra Somanathan Nair
Drishya Nishanth
Radhakrishnan Subramanian
Xiulan Xie
Maozhi Ren
Abdul Jaleel

Keywords

Medicinal plants, conservation, stress factors, sustainability, aquaponics, drug development

Abstract

Medicinal plants are one of the significant elements of global population that play a pivotal role in healthcare and other sectors. The cultivation and trade of medicinal plants hold considerable economic value for a country. However, the interplay of climate change, intensive harvesting, and other stress factors has resulted in a decline in the availability of medicinal plants, leading to a loss of their medicinal properties and, in extreme cases, species extinction. Despite the existence of numerous recommendations aimed at conserving and sustainably utilizing medicinal plant resources, only a limited number of these initiatives have successfully safeguarded some medicinal plant species. This review aims to highlight the significance of conservation of medicinal plants by aquaponics, a sustainable approach integrating aquaculture and hydroponics. The review discusses stress factors affecting the survival of medicinal plants and various applications of medicinal plants in new drug development. Studies providing evidence of aquaponics grown medicinal plants with enhanced performance and medicinal properties were discussed. Future research work can focus more on expanding the scope of utilizing aquaponics to grow and protect a wider array of medicinal plant species. Such an approach will potentially conserve medicinal plants from climate change, exploitative practices, species extinction and can be utilized for novel drug development.

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References

1. Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action. International journal of molecular sciences. 2017 Mar 17;18(3):656. https://doi.org/10.3390/ijms18030656
2. Nalawade SM, Sagare AP, Lee CY, Kao CL, Tsay HS. Studies on tissue culture of Chinese medicinal plant resources in Taiwan and their sustainable utilization. Bot. Bull. Acad. Sin. 2003 Apr 1;44(2):79-98. DOI: 10.1079/IVP2003504.
3. Cole IB, Saxena PK, Murch SJ. Medicinal biotechnology in the genus Scutellaria. In Vitro Cellular & Developmental Biology–Plant. 2007 Aug;43:318-27. https://doi.org/10.1007/s11627-007-9055-4
4. Vines G. Herbal harvests with a future: towards sustainable sources for medicinal plants. Plantlife International; 2004.
5. Katerere DR, Luseba D, editors. Ethnoveterinary botanical medicine: herbal medicines for animal health. CRC Press; 2010 Jun 23.
6. Brinckmann JA. Sustainable Sourcing: Markets for certified Chinese medicinal and aromatic Plants. Geneva: International Trade Centre. 2016;22.
7. Bentley R, editor. Medicinal plants. London: Domville-Fife Press; 2010. p. 23–46.
8. Ross IA. Medicinal plants of the world, volume 3: Chemical constituents, traditional and modern medicinal uses. Springer Science & Business Media; 2007 Oct 28.
9. Heywood VH, Iriondo JM. Plant conservation: old problems, new perspectives. Biological conservation. 2003 Oct 1;113(3):321-35. https://doi.org/10.1016/S0006-3207(03)00121-6
10. Hamilton AC. Medicinal plants in conservation and development case studies and lessons learnt.
11. Zerabruk S, Yirga G. Traditional knowledge of medicinal plants in Gindeberet district, Western Ethiopia. South African Journal of Botany. 2012 Jan 1;78:165-9. https://doi.org/10.1016/j.sajb.2011.06.006
12. Sakkir S, Kabshawi M, Mehairbi M. Medicinal plants diversity and their conservation status in the United Arab Emirates (UAE). J Med Plants Res. 2012 Feb 23;6(7):1304-22. DOI: 10.5897/JMPR11.1412
13. Solomon SD. Contribution of Working Group I to the fourth assessment report of the Intergovernmental Panel on Climate Change 2007. 2007.
14. Parmesan C. Ecological and evolutionary responses to recent climate change. Annu. Rev. Ecol. Evol. Syst. 2006 Dec 1;37(1):637-69. https://doi.org/10.1146/annurev.ecolsys.37.091305.110100
15. Salick J, Fang Z, Byg A. Eastern Himalayan alpine plant ecology, Tibetan ethnobotany, and climate change. Global Environmental Change. 2009 May 1;19(2):147-55. https://doi.org/10.1016/j.gloenvcha.2009.01.008
16. Loarie SR, Duffy PB, Hamilton H, Asner GP, Field CB, Ackerly DD. The velocity of climate change. Nature. 2009 Dec 24;462(7276):1052-5. https://doi.org/10.1038/nature08649
17. Huang J, Wang P, Niu Y, Yu H, Ma F, Xiao G, Xu X. Changes in C:N:P stoichiometry modify N and P conservation strategies of a desert steppe species Glycyrrhiza uralensis. Scientific reports. 2018 Aug 23;8(1):12668. https://doi.org/10.1038/s41598-018-30324-w
18. Welch RM, Graham RD. Breeding for micronutrients in staple food crops from a human nutrition perspective. Journal of experimental botany. 2004 Feb 1;55(396):353-64. https://doi.org/10.1093/jxb/erh064
19. Davis DR. Declining fruit and vegetable nutrient composition: what is the evidence?. HortScience. 2009 Feb 1;44(1):15-9. https://doi.org/10.21273/HORTSCI.44.1.15
20. Bøhn T, Cuhra M, Traavik T, Sanden M, Fagan J, Primicerio R. Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans. Food chemistry. 2014 Jun 15;153:207-15. https://doi.org/10.1016/j.foodchem.2013.12.054
21. Figàs MR, Prohens J, Raigón MD, Fita A, García-Martínez MD, Casanova C, Borràs D, Plazas M, Andújar I, Soler S. Characterization of composition traits related to organoleptic and functional quality for the differentiation, selection and enhancement of local varieties of tomato from different cultivar groups. Food Chemistry. 2015 Nov 15;187:517-24. https://doi.org/10.1016/j.foodchem.2015.04.083
22. Elevation-dependent warming in mountain regions of the world. Nature Climate Change. 2015;5(5):424-430.
23. Firenzuoli F, Gori L. Herbal medicine today: clinical and research issues. Evidence‐Based Complementary and Alternative Medicine. 2007;4:37-40. https://doi.org/10.1093/ecam/nem096
24. Nasim N, Sandeep IS, Mohanty S. Plant-derived natural products for drug discovery: current approaches and prospects. The Nucleus. 2022 Dec;65(3):399-411. https://doi.org/10.1007/s13237-022-00405-3
25. Ortega‐Ramirez LA, Rodriguez‐Garcia I, Leyva JM, Cruz‐Valenzuela MR, Silva‐Espinoza BA, Gonzalez‐Aguilar GA, Siddiqui MW, Ayala‐Zavala JF. Potential of medicinal plants as antimicrobial and antioxidant agents in food industry: a hypothesis. Journal of food science. 2014 Feb;79(2):R129-37. https://doi.org/10.1111/1750-3841.12341
26. Abbasi AM, Khan MA, Ahmad M, Zafar M, Jahan S, Sultana S. Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. Journal of ethnopharmacology. 2010 Mar 24;128(2):322-35. https://doi.org/10.1016/j.jep.2010.01.052
27. Greff B, Sáhó A, Lakatos E, Varga L. Biocontrol activity of aromatic and medicinal plants and their bioactive components against soil-borne pathogens. Plants. 2023 Feb 5;12(4):706. https://doi.org/10.3390/plants12040706
28. Pasierski M, Szulczyk B. Beneficial effects of capsaicin in disorders of the central nervous system. Molecules. 2022 Apr 12;27(8):2484. https://doi.org/10.3390/molecules27082484
29. Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M. A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). Journal of evidence-based complementary & alternative medicine. 2016 Jan;21(1):53-62. https://doi.org/10.1177/2156587215583405
30. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, Mu DZ, Du JB, Li GH, Wallenstein S, Sampson H. Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. Journal of allergy and clinical immunology. 2005 Sep 1;116(3):517-24. https://doi.org/10.1016/j.jaci.2005.05.029
31. Lone SH, Bhat KA, Khuroo MA. Arglabin: From isolation to antitumor evaluation. Chemico-Biological Interactions. 2015 Oct 5;240:180-98. https://doi.org/10.1016/j.cbi.2015.08.015
32. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. The American Journal of Gastroenterology. 1998 Feb 1;93(2):139-43. https://doi.org/10.1016/S0002-9270(97)00082-8
33. Shah GM, Khan MA. Common medicinal folk recipes of siran valley, Mansehra, Pakistan. Ethnobotanical Leaflets. 2006;2006(1):5.
34. Ahmed M, Khan MA, Zafar M, Sultana S. Treatment of common ailments by plant-based remedies among the people of district Attock (Punjab) of Northern Pakistan. African Journal of Traditional, Complementary and Alternative Medicines. 2007 Feb 8;4(1):112-20. 10.4314/ajtcam.v4i1.31201
35. Ahmad SS, Husain SZ. Ethno medicinal survey of plants from salt range (Kallar Kahar) of Pakistan. Pak J Bot. 2008 Jun 1;40(3):1005-11.
36. Jan G, Khan MA, Jan F. Traditional medicinal and economic uses of gymnosperms of Dir Kohistan Valleys, NWFP, Pakistan. Ethnobotanical Leaflets. 2009;2009(12):9.
37. Banerjee A, Roychoudhury A. Effect of salinity stress on growth and physiology of medicinal plants. Medicinal plants and environmental challenges. 2017:177-88. https://doi.org/10.1007/978-3-319-68717-9_10
38. Neffati M, Marzouk B. Changes in essential oil and fatty acid composition in coriander (Coriandrum sativum L.) leaves under saline conditions. Industrial Crops and Products. 2008 Sep 1;28(2):137-42. https://doi.org/10.1016/j.indcrop.2008.02.005
39. Baatour O, Kaddour R, Aidi Wannes W, Lachaal M, Marzouk B. Salt effects on the growth, mineral nutrition, essential oil yield and composition of marjoram (Origanum majorana). Acta Physiologiae Plantarum. 2010 Jan;32:45-51. https://doi.org/10.1007/s11738-009-0374-4
40. Souther S, McGraw JB. Synergistic effects of climate change and harvest on extinction risk of American ginseng. Ecological Applications. 2014 Sep;24(6):1463-77. https://doi.org/10.1890/13-0653.1
41. McElhaney JE, Simor AE, McNeil S, Predy GN. Efficacy and Safety of CVT‐E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza‐Vaccinated Community‐Dwelling Adults. Influenza Research and Treatment. 2011;2011:759051. https://doi.org/10.1155/2011/759051
42. Seida JK, Durec T, Kuhle S. North American (Panax quinquefolius) and Asian Ginseng (Panax ginseng) preparations for prevention of the common cold in healthy adults: a systematic review. Evidence‐Based Complementary and Alternative Medicine. 2011;2011:282151. https://doi.org/10.1093/ecam/nep068
43. Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, McGinn TW, Stella PJ, Seeger GR, Sood A, Loprinzi CL. Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. Journal of the National Cancer Institute. 2013 Aug 21;105(16):1230-8. https://doi.org/10.1093/jnci/djt181
44. Mucalo I, Jovanovski E, Rahelić D, Božikov V, Romić Ž, Vuksan V. Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension. Journal of Ethnopharmacology. 2013 Oct 28;150(1):148-53. https://doi.org/10.1016/j.jep.2013.08.015
45. McGraw JB. Evidence for decline in stature of American ginseng plants from herbarium specimens. Biological Conservation. 2001 Mar 1;98(1):25-32. https://doi.org/10.1016/S0006-3207(00)00138-5
46. Case MA, Flinn KM, Jancaitis J, Alley A, Paxton A. Declining abundance of American ginseng (Panax quinquefolius L.) documented by herbarium specimens. Biological Conservation. 2007 Jan 1;134(1):22-30. https://doi.org/10.1016/j.biocon.2006.07.018
47. Mulligan MR. Population loss of goldenseal, Hydrastis canadensis L. (Ranunculaceae), in Ohio. Miami University; 2003.
48. Law W, Salick J. Human-induced dwarfing of Himalayan snow lotus, Saussurea laniceps (Asteraceae). Proceedings of the National Academy of Sciences. 2005 Jul 19;102(29):10218-20. https://doi.org/10.1073/pnas.0502931102
49. Gad HA, El-Ahmady SH, Abou-Shoer MI, Al-Azizi MM. Application of chemometrics in authentication of herbal medicines: a review. Phytochemical Analysis. 2013 Jan;24(1):1-24. https://doi.org/10.1002/pca.2378
50. Singh RJ, Jauhar PP. Genetic Resources, Chromosome Engineering, and Crop Improvement: Cereals, Volume 2. CRC Press; 2006 Jan 13. https://doi.org/10.1201/9780203489260
51. Applequist WL, Brinckmann JA, Cunningham AB, Hart RE, Heinrich M, Katerere DR, Van Andel T. Scientists’ warning on climate change and medicinal plants. Planta Medica. 2020 Jan;86(01):10-8. DOI: 10.1055/a-1041-3406
52. Goddek S, Joyce A, Kotzen B, Burnell GM. Aquaponics food production systems: combined aquaculture and hydroponic production technologies for the future. Springer Nature; 2019.
53. Reinhardt T, Hoevenaars K, Joyce A. Regulatory frameworks for aquaponics in the European Union. Aquaponics Food Production Systems. 2019:501-22.
54. Pezzuto JM. Natural product cancer chemopreventive agents. In: Phytochemistry of medicinal plants. Springer US; 1995. p. 19-45. https://doi.org/10.1007/978-1-4899-1778-2_2
55. Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Natural Product Reports. 2000;17(3):215-34.
56. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. Journal of Natural Products. 2003 Jul 25;66(7):1022-37. https://doi.org/10.1021/np030096l
57. Bentley R, editor. Medicinal plants. London: Domville-Fife Press; 2010. p. 23–46.
58. Ross IA. Medicinal plants of the world, volume 3: Chemical constituents, traditional and modern medicinal uses. Springer Science & Business Media; 2007 Oct 28.
59. Heywood VH, Iriondo JM. Plant conservation: old problems, new perspectives. Biological Conservation. 2003 Oct 1;113(3):321-35. https://doi.org/10.1016/S0006-3207(03)00121-6
60. Hamilton AC. Medicinal plants in conservation and development case studies and lessons learnt.
61. Zerabruk S, Yirga G. Traditional knowledge of medicinal plants in Gindeberet district, Western Ethiopia. South African Journal of Botany. 2012 Jan 1;78:165-9. https://doi.org/10.1016/j.sajb.2011.06.006
62. Sakkir S, Kabshawi M, Mehairbi M. Medicinal plants diversity and their conservation status in the United Arab Emirates (UAE). Journal of Medicinal Plants Research. 2012 Feb 23;6(7):1304-22. DOI: 10.5897/JMPR11.1412
63. Solomon SD. Contribution of Working Group I to the fourth assessment report of the Intergovernmental Panel on Climate Change 2007. 2007.
64. Parmesan C. Ecological and evolutionary responses to recent climate change. Annual Review of Ecology, Evolution, and Systematics. 2006;37:637-69. https://doi.org/10.1146/annurev.ecolsys.37.091305.110100
65. Salick J, Fang Z, Byg A. Eastern Himalayan alpine plant ecology, Tibetan ethnobotany, and climate change. Global Environmental Change. 2009 May 1;19(2):147-55. https://doi.org/10.1016/j.gloenvcha.2009.01.008
66. Loarie SR, Duffy PB, Hamilton H, Asner GP, Field CB, Ackerly DD. The velocity of climate change. Nature. 2009 Dec 24;462(7276):1052-5. https://doi.org/10.1038/nature08649
67. Huang J, Wang P, Niu Y, Yu H, Ma F, Xiao G, Xu X. Changes in C:N:P stoichiometry modify N and P conservation strategies of a desert steppe species Glycyrrhiza uralensis. Scientific Reports. 2018 Aug 23;8(1):12668. https://doi.org/10.1038/s41598-018-30324-w
68. Welch RM, Graham RD. Breeding for micronutrients in staple food crops from a human nutrition perspective. Journal of Experimental Botany. 2004 Feb 1;55(396):353-64. https://doi.org/10.1093/jxb/erh064
69. Davis DR. Declining fruit and vegetable nutrient composition: what is the evidence?. HortScience. 2009 Feb 1;44(1):15-9. https://doi.org/10.21273/HORTSCI.44.1.15
70. Bøhn T, Cuhra M, Traavik T, Sanden M, Fagan J, Primicerio R. Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans. Food Chemistry. 2014 Jun 15;153:207-15. https://doi.org/10.1016/j.foodchem.2013.12.054
71. Figàs MR, Prohens J, Raigón MD, Fita A, García-Martínez MD, Casanova C, Borràs D, Plazas M, Andújar I, Soler S. Characterization of composition traits related to organoleptic and functional quality for the differentiation, selection and enhancement of local varieties of tomato from different cultivar groups. Food Chemistry. 2015 Nov 15;187:517-24. https://doi.org/10.1016/j.foodchem.2015.04.083
72. Elevation-dependent warming in mountain regions of the world. Nature Climate Change. 2015;5(5):424-430.
73. Firenzuoli F, Gori L. Herbal medicine today: clinical and research issues. Evidence-Based Complementary and Alternative Medicine. 2007;4:37-40. https://doi.org/10.1093/ecam/nem096
74. Nasim N, Sandeep IS, Mohanty S. Plant-derived natural products for drug discovery: current approaches and prospects. The Nucleus. 2022 Dec;65(3):399-411. https://doi.org/10.1007/s13237-022-00405-3
75. Ortega-Ramirez LA, Rodriguez-Garcia I, Leyva JM, Cruz-Valenzuela MR, Silva-Espinoza BA, Gonzalez-Aguilar GA, Siddiqui MW, Ayala-Zavala JF. Potential of medicinal plants as antimicrobial and antioxidant agents in food industry: a hypothesis. Journal of Food Science. 2014 Feb;79(2):R129-37. https://doi.org/10.1111/1750-3841.12341
76. Abbasi AM, Khan MA, Ahmad M, Zafar M, Jahan S, Sultana S. Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. Journal of Ethnopharmacology. 2010 Mar 24;128(2):322-35. https://doi.org/10.1016/j.jep.2010.01.052
77. Greff B, Sáhó A, Lakatos E, Varga L. Biocontrol activity of aromatic and medicinal plants and their bioactive components against soil-borne pathogens. Plants. 2023 Feb 5;12(4):706. https://doi.org/10.3390/plants12040706
78. Pasierski M, Szulczyk B. Beneficial effects of capsaicin in disorders of the central nervous system. Molecules. 2022 Apr 12;27(8):2484. https://doi.org/10.3390/molecules27082484
79. Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M. A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). Journal of Evidence-Based Complementary & Alternative Medicine. 2016 Jan;21(1):53-62. https://doi.org/10.1177/2156587215583405
80. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, Mu DZ, Du JB, Li GH, Wallenstein S, Sampson H. Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. Journal of Allergy and Clinical Immunology. 2005 Sep 1;116(3):517-24. https://doi.org/10.1016/j.jaci.2005.05.029
81. Bentley R, editor. Medicinal plants. London: Domville-Fife Press; 2010. p. 23–46.
82. Ross IA. Medicinal plants of the world, volume 3: Chemical constituents, traditional and modern medicinal uses. Springer Science & Business Media; 2007 Oct 28.
83. Heywood VH, Iriondo JM. Plant conservation: old problems, new perspectives. Biological Conservation. 2003 Oct 1;113(3):321-35. https://doi.org/10.1016/S0006-3207(03)00121-6
84. Hamilton AC. Medicinal plants in conservation and development case studies and lessons learnt.
85. Applequist WL, Brinckmann JA, Cunningham AB, Hart RE, Heinrich M, Katerere DR, Van Andel T. Scientists’ warning on climate change and medicinal plants. Planta Medica. 2020 Jan;86(01):10-8. DOI: 10.1055/a-1041-3406
86. Goddek S, Joyce A, Kotzen B, Burnell GM. Aquaponics food production systems: combined aquaculture and hydroponic production technologies for the future. Springer Nature; 2019.
87. Reinhardt T, Hoevenaars K, Joyce A. Regulatory frameworks for aquaponics in the European Union. Aquaponics Food Production Systems. 2019:501-22.
88. Pezzuto JM. Natural product cancer chemopreventive agents. In: Phytochemistry of medicinal plants. Springer US; 1995. p. 19-45. https://doi.org/10.1007/978-1-4899-1778-2_2
89. Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Natural Product Reports. 2000;17(3):215-34.
90. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. Journal of Natural Products. 2003 Jul 25;66(7):1022-37. https://doi.org/10.1021/np030096l
91. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. Journal of Natural Products. 2003 Jul 25;66(7):1022-37. https://doi.org/10.1021/np030096l
92. Heinrich M, Barnes J, Gibbons S, Williamson EM. Fundamentals of Pharmacognosy and Phytotherapy. Churchill Livingstone; 2004.
93. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006 Feb;27(1):1-93. https://doi.org/10.1016/j.mam.2005.07.008
94. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives. 2001 Mar;109(Suppl 1):69-75.
95. Rates SMK. Plants as source of drugs. Toxicon. 2001 May;39(5):603-13.
96. Harvey AL. Natural products in drug discovery. Drug Discovery Today. 2008 Sep;13(19-20):894-901. https://doi.org/10.1016/j.drudis.2008.07.004
97. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. Journal of Natural Products. 2007 Mar;70(3):461-77. https://doi.org/10.1021/np068054v
98. Butler MS. Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports. 2008 Apr;25(3):475-516.
99. Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta. 2013 Jun;1830(6):3670-95.
100. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nature Reviews Drug Discovery. 2005 Mar;4(3):206-20.
101. Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sciences. 2005 Apr;78(5):431-41.
102. Verpoorte R, Choi YH, Kim HK. Ethnopharmacology and systems biology: a perfect holistic match. Journal of Ethnopharmacology. 2005 Aug;100(1-2):53-6.
103. Wang Z, Wang N, Han S, Wang D, Mo S, Yu L, Huang H. Dietary compounds and phytochemicals in cancer prevention: mechanisms of action. Journal of Integrative Medicine. 2015 Jan;13(1):1-15.
104. Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. American Journal of Clinical Nutrition. 2003 Sep;78(3 Suppl):517S-520S.
105. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition. 2004 May;79(5):727-47.
106. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):215S-217S.
107. Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports. 2009 Aug;26(8):1001-43.
108. Duthie GG, Gardner PT, Kyle JAM. Plant polyphenols: are they the new magic bullet? Proceedings of the Nutrition Society. 2003 May;62(3):599-603.
109. Williamson G, Clifford MN. Colonic metabolites of berry polyphenols: the missing link to biological activity? British Journal of Nutrition. 2010 Apr;104(Suppl 3):S48-66.
110. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Scientific World Journal. 2013;2013:162750.
111. Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM. Flavonoids: a review of probable mechanisms of action and potential applications. American Journal of Clinical Nutrition. 2001 Oct;74(4):418-25.
112. Pietta PG. Flavonoids as antioxidants. Journal of Natural Products. 2000 Jul;63(7):1035-42.
113. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure–activity relationships. Journal of Nutritional Biochemistry. 2002 Oct;13(10):572-84.
114. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews. 2000 Dec;52(4):673-751.
115. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. Journal of Nutrition. 2000 Aug;130(8S Suppl):2073S-2085S.
116. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutrition Reviews. 1998 Nov;56(11):317-33.
117. Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annual Review of Nutrition. 2002;22:19-34.
118. Hertog MGL, Hollman PCH, Katan MB. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. Journal of Agricultural and Food Chemistry. 1992 Sep;40(12):2379-83.
119. Hollman PCH, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food and Chemical Toxicology. 1999 Sep;37(9-10):937-42.
120. Aherne SA, O’Brien NM. Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 2002 Jan;18(1):75-81.
121. Clifford MN. Diet-derived phenols in plasma and tissues and their implications for health. Planta Medica. 2004 Nov;70(12):1103-14.
122. Croft KD. The chemistry and biological effects of flavonoids and phenolic acids. Annals of the New York Academy of Sciences. 1998 Nov;854:435-42.
123. Del Rio D, Costa LG, Lean MEJ, Crozier A. Polyphenols and health: what compounds are involved? Nutrition, Metabolism & Cardiovascular Diseases. 2010 Jan;20(1):1-6.
124. Del Rio D, Rodriguez-Mateos A, Spencer JPE, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects. Antioxidants & Redox Signaling. 2013 Apr;18(14):1818-92.
125. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):230S-242S.
126. Spencer JPE. Flavonoids: modulators of brain function? British Journal of Nutrition. 2008 Oct;99(E Suppl 1):ES60-77.
127. Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxidative Medicine and Cellular Longevity. 2012;2012:914273.
128. Williams RJ, Spencer JPE, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Free Radical Biology & Medicine. 2004 Apr;36(7):838-49.
129. Rice-Evans C. Flavonoid antioxidants. Current Medicinal Chemistry. 2001 Aug;8(7):797-807.
130. Kris-Etherton PM, Keen CL. Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Current Opinion in Lipidology. 2002 Feb;13(1):41-9.
131. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):317S-325S.
132. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 1992 Jun;339(8808):1523-6.
133. Cassidy A, Rimm EB, O’Reilly EJ, Logroscino G, Kay C, Chiuve SE, Rexrode KM. Dietary flavonoids and risk of stroke in women. Stroke. 2012 Apr;43(4):946-51.
134. Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T, Aromaa A. Flavonoid intake and risk of chronic diseases. American Journal of Clinical Nutrition. 2002 May;76(3):560-8.
135. Hertog MGL, Feskens EJM, Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet. 1993 Oct;342(8878):1007-11.
136. Hollman PCH, Geelen A, Kromhout D. Dietary flavonol intake may lower stroke risk. Archives of Internal Medicine. 2010 Mar;170(16):1540-7.
137. Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr. Flavonoid intake and cardiovascular disease mortality. American Journal of Clinical Nutrition. 2007 Mar;85(3):895-909.
138. Peterson J, Dwyer J. Flavonoids: dietary occurrence and biochemical activity. Nutrition Research. 1998 Dec;18(12):1995-2018.
139. Hollman PCH. Evidence for health benefits of plant phenols: local or systemic effects? Journal of the Science of Food and Agriculture. 2001 Jan;81(9):842-52.
140. Scalbert A, Morand C, Manach C, Rémésy C. Absorption and metabolism of polyphenols in the gut and impact on health. Biomedicine & Pharmacotherapy. 2002 Sep;56(6):276-82.
141. D’Archivio M, Filesi C, Vari R, Scazzocchio B, Masella R. Bioavailability of the polyphenols: status and controversies. International Journal of Molecular Sciences. 2010 Apr;11(4):1321-42.
142. Landete JM. Plant and mammalian lignans: a review of source, intake, metabolism, intestinal bacteria and health. Food Research International. 2012 Aug;46(1):410-24.
143. Selma MV, Espín JC, Tomás-Barberán FA. Interaction between phenolics and gut microbiota. Journal of Agricultural and Food Chemistry. 2009 Aug;57(15):6485-501.
144. Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. Journal of Nutritional Biochemistry. 2013 Aug;24(8):1415-22.
145. Ozdal T, Sela DA, Xiao J, Boyacioglu D, Chen F, Capanoglu E. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients. 2016 Feb;8(2):78.
146. Clifford MN, van der Hooft JJJ, Crozier A. Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols. American Journal of Clinical Nutrition. 2013 Jan;98(6 Suppl):1619S-1630S.
147. Del Rio D, Borges G, Crozier A. Berry flavonoids and phenolics: bioavailability and evidence of protective effects. British Journal of Nutrition. 2010 Apr;104(Suppl 3):S67-90.
148. Rodriguez-Mateos A, Heiss C, Borges G, Crozier A. Berry (poly)phenols and cardiovascular health. Journal of Agricultural and Food Chemistry. 2014 May;62(18):3842-51.
149. Manach C, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Current Opinion in Lipidology. 2005 Feb;16(1):77-84.
150. Crozier A, Del Rio D, Clifford MN. Bioavailability of dietary flavonoids and phenolic compounds. Molecular Aspects of Medicine. 2010 Dec;31(6):446-67.
151. Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):243S-255S.
152. Hollman PCH. Absorption, bioavailability, and metabolism of flavonoids. Pharmaceutical Biology. 2004 Jan;42(Suppl 1):74-83.
153. Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Nutrition Research. 2004 Oct;24(10):851-74.
154. Petersen B, Egert S, Bosy-Westphal A, Müller MJ, Wolffram S, Hubbermann EM, Rimbach G, Schwarz K. Bioavailability of quercetin in humans and the influence of food matrix. Journal of Nutrition. 2016 Feb;146(2):266-74.
155. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition. 2004 May;79(5):727-47.
156. Cermak R, Wolffram S. The potential of flavonoids to influence drug metabolism and pharmacokinetics by modulation of cytochrome P450 enzymes. Current Drug Metabolism. 2006 Jun;7(6):729-38.
157. Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicology in Vitro. 2006 Jun;20(2):187-210.
158. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. Journal of Nutrition. 2003 Oct;133(10):3262S-3267S.
159. Yang CS, Wang H. Cancer preventive activities of tea catechins. Molecules. 2016 Dec;21(12):1679.
160. Khan N, Mukhtar H. Tea polyphenols in promotion of human health. Nutrients. 2019 Jan;11(1):39.
161. Friedman M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Molecular Nutrition & Food Research. 2007 Jan;51(1):116-34.
162. Steinmann J, Buer J, Pietschmann T, Steinmann E. Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. British Journal of Pharmacology. 2013 Jan;168(5):1059-73.
163. Dufresne CJ, Farnworth ER. A review of latest research findings on the health promotion properties of tea. Journal of Nutritional Biochemistry. 2001 Jul;12(7):404-21.
164. Cabrera C, Artacho R, Giménez R. Beneficial effects of green tea—a review. Journal of the American College of Nutrition. 2006 Apr;25(2):79-99.
165. Khan N, Mukhtar H. Green tea polyphenols in chemoprevention of prostate cancer. Journal of Nutrition. 2008 Dec;138(12):246S-252S.
166. Thielecke F, Boschmann M. The potential role of green tea catechins in the prevention of the metabolic syndrome. British Journal of Nutrition. 2009 Jul;102(1):1-18.
167. Yang CS, Hong J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Annual Review of Nutrition. 2013;33:161-81.
168. Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MBH. Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders. Molecular Nutrition & Food Research. 2006 Feb;50(2):229-34.
169. Mandel SA, Youdim MBH. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radical Biology & Medicine. 2004 Nov;37(3):304-17.
170. Weinreb O, Mandel S, Amit T, Youdim MBH. Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases. Journal of Nutritional Biochemistry. 2004 Sep;15(9):506-16.
171. Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):313S-316S.
172. Spencer JPE. The impact of fruit flavonoids on memory and cognition. British Journal of Nutrition. 2010 Apr;104(Suppl 3):S40-7.
173. Vauzour D, Rodriguez-Mateos A, Corona G, Oruna-Concha MJ, Spencer JPE. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients. 2010 Nov;2(11):1106-31.
174. Manach C, Hubbermann EM. Absorption and metabolism of polyphenols in humans. Annual Review of Nutrition. 2006;26:215-35.
175. Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports. 2009 Aug;26(8):1001-43.
176. Del Rio D, Costa LG, Lean MEJ, Crozier A. Polyphenols and health: what compounds are involved? Nutrition, Metabolism & Cardiovascular Diseases. 2010 Jan;20(1):1-6.
177. Arts ICW, Hollman PCH. Polyphenols and disease risk in epidemiologic studies. American Journal of Clinical Nutrition. 2005 Jan;81(1 Suppl):317S-325S.
178. Applequist WL, Brinckmann JA, Cunningham AB, Hart RE, Heinrich M, Katerere DR, Van Andel T. Scientists’ warning on climate change and medicinal plants. Planta Medica. 2020 Jan;86(01):10-8. DOI: 10.1055/a-1041-3406

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