Increased Global Burden of Pediatric Infectious Diseases: Updates on Diagnosis, Management, and Vaccination Strategies
Main Article Content
Keywords
Pediatric Infectious Diseases, Global Burden, Vaccination Strategies, Management, Diagnosis, Outbreaks, Pandemics, Epidemics
Abstract
The increasing global burden of pediatric infectious diseases poses a significant public health concern, particularly in low- and middle-income countries. This review article provides an overview of major pediatric infectious diseases, their impact on child health and public health, and updates on diagnosis, management, and vaccination strategies. The burden of pediatric infectious diseases is influenced by factors such as poverty, malnutrition, inadequate sanitation, and limited access to healthcare services. Infectious diseases account for approximately 25% of all deaths in children under the age of five globally. The review addresses research questions related to diagnostic methods, treatment approaches, vaccination strategies, and potential future directions for reducing the burden of pediatric infectious diseases. Advances in diagnostic techniques have improved the ability to accurately diagnose pediatric infectious diseases, but challenges remain, especially in resource-limited settings. Antimicrobial therapy, supportive care measures, infection prevention and control strategies, and vaccination are important components of comprehensive management. The review highlights the importance of the recommended childhood vaccination schedule, the effectiveness of existing vaccines, and ongoing developments in vaccine research. Integrated management approaches, such as IMCI and ICCM, are discussed as strategies to improve diagnosis and management at both healthcare and community levels. Addressing global disparities requires overcoming challenges and barriers through innovative approaches, collaboration, and capacity-building efforts. The implications for practice, policy, and future research emphasize the need for awareness, knowledge, and interventions to reduce the burden of pediatric infectious diseases worldwide.
References
1. Azage M, Kumie A, Worku A, Bagtzoglou AC. Childhood diarrhea in high and low hotspot districts of Amhara Region, northwest Ethiopia: a multilevel modeling. J Health Popul Nutr [Internet]. 2016 May 16 [cited 2023 Jul 4];35(1):13. Available from: https://jhpn.biomedcentral.com/articles/10.1186/s41043-016-0052-2
2. Mihalopoulos M, Levine AC, Marayati NF, Chubak BM, Archer M, Badani KK, et al. The Resilient Child: Sex-Steroid Hormones and COVID-19 Incidence in Pediatric Patients. J Endocr Soc [Internet]. 2020 Sep 1 [cited 2023 Jul 4];4(9). Available from: https://dx.doi.org/10.1210/jendso/bvaa106
3. Dietert RR, Zelikoff JT. Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma. Birth Defects Res B Dev Reprod Toxicol [Internet]. 2008 Dec 1 [cited 2023 Jul 4];83(6):547–60. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/bdrb.20170
4. Odatuwa-Omagbemi DO, Izuagba E, Enemudo RE, Otene CI, Ijezie NC, Odatuwa-Omagbemi DO, et al. Epidemiological Pattern of Musculoskeletal Injuries in Children Aged 16 Years and Below in a Regional Trauma Centre in Nigeria. Cureus [Internet]. 2023 Apr 25 [cited 2023 Jul 4];15(4). Available from: https://www.cureus.com/articles/144879-epidemiological-pattern-of-musculoskeletal-injuries-in-children-aged-16-years-and-below-in-a-regional-trauma-centre-in-nigeria
5. Chen C, Guan Z, Huang C, Jiang D, Liu X, Zhou Y, et al. Epidemiological Trends and Hotspots of Other Infectious Diarrhea (OID) in Mainland China: A Population-Based Surveillance Study From 2004 to 2017. Front Public Health. 2021 Jul 22;9:679853.
6. Omondi I, Odiere MR, Rawago F, Mwinzi PN, Campbell C, Musuva R. Socioeconomic determinants of Schistosoma mansoni infection using multiple correspondence analysis among rural western Kenyan communities: Evidence from a household-based study. PLoS One [Internet]. 2021 Jun 1 [cited 2023 Jul 4];16(6):e0253041. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253041
7. Ferreira AA, Santos RV, Souza JAM de, Welch JR, Coimbra CEA. Anemia e níveis de hemoglobina em crianças indígenas Xavante, Brasil Central. Rev Bras Epidemiol [Internet]. 2017 [cited 2023 Jul 4];20(1):102–14. Available from: https://www.scielo.br/j/rbepid/a/bxY8zVDs5BZXzPCcxc4kxRF/?lang=pt
8. Halverson S, Malani PN, Newton DW, Habicht A, Vander Have K, Younger JG. Impact of hourly emergency department patient volume on blood culture contamination and diagnostic yield. J Clin Microbiol [Internet]. 2013 Jun [cited 2023 Jul 8];51(6):1721–6. Available from: https://journals.asm.org/doi/10.1128/jcm.03422-12
9. Agulnik A, Mora Robles LN, Forbes PW, Soberanis Vasquez DJ, Mack R, Antillon-Klussmann F, et al. Improved outcomes after successful implementation of a pediatric early warning system (PEWS) in a resource-limited pediatric oncology hospital. Cancer [Internet]. 2017 Aug 1 [cited 2023 Jul 8];123(15):2965–74. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.30664
10. Buonsenso D, Serranti D, Focarelli B, Chiaretti A, Calzedda R, Valentini P. How to manage TB in children? Problems and solutions in four cases. Open Med (Poland) [Internet]. 2015 Jan 1 [cited 2023 Jul 8];10(1):63–9. Available from: https://www.degruyter.com/document/doi/10.1515/med-2015-0012/html
11. Piccolo G, De Rose EL, Bassi M, Napoli F, Minuto N, Maghnie M, et al. Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review. Front Endocrinol (Lausanne). 2022 Aug 24;13:966344.
12. Verma DJ, Ahirwal DK, Patel DU, Shingwekar DAG, Sharma DrS. Clinical profile of tuberculosis in children up to 5 years of age. Pediatr Rev Int J Pediatr Res [Internet]. 2014 Apr 30 [cited 2023 Jul 8];1(1):10–6. Available from: https://pediatrics.medresearch.in/index.php/ijpr/article/view/3/6
13. El Nady HG, Kholoussi N, Sherif LS, El Baroudy NR, El Refay AS, Abdelkawy RFM, et al. Triggering receptor expressed on myeloid cells-1 (TREM-1) as a new marker in ventilated children with pneumonia. Biomed Pharmacol J. 2019;12(4):1951–9.
14. Chen MF, Wang RH, Schneider JK, Tsai CT, Dah-Shyong Jiang D, Hung MN, et al. Using the health belief model to understand caregiver factors influencing childhood influenza vaccinations. J Community Health Nurs. 2011;28(1):29–40.
15. Principi N, Esposito S. Infectious Discitis and Spondylodiscitis in Children. Int J Mol Sci [Internet]. 2016 Apr 9 [cited 2023 Jul 8];17(4):539. Available from: https://www.mdpi.com/1422-0067/17/4/539/htm
16. Semmes EC, Chen JL, Goswami R, Burt TD, Permar SR, Fouda GG. Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health. Front Immunol. 2021 Jan 21;11:595297.
17. Barman S, Soni D, Brook B, Nanishi E, Dowling DJ. Precision Vaccine Development: Cues From Natural Immunity. Front Immunol. 2022 Feb 10;12:662218.
18. Eden LM, Macintosh JL, Luthy KE, Beckstrand RL. Minimizing pain during childhood vaccination injections: improving adherence to vaccination schedules. Pediatr Health Med Ther [Internet]. 2014 Sep 30 [cited 2023 Jul 8];5:127–40. Available from: https://www.dovepress.com/minimizing-pain-during-childhood-vaccination-injections-improving-adhe-peer-reviewed-fulltext-article-PHMT
19. Cacciatore MA, Nowak G, Evans NJ. Exploring The Impact Of The US Measles Outbreak On Parental Awareness Of And Support For Vaccination [Internet]. 2017 Aug 2 [cited 2023 Jul 8];35(2):334–40. Available from: https://doi.org/10.1377/hlthaff.2015.1093
20. Aaron D, Nagu TJ, Rwegasha J, Komba E. Hepatitis B vaccination coverage among healthcare workers at national hospital in Tanzania: How much, who and why? BMC Infect Dis [Internet]. 2017 Dec 20 [cited 2023 Jul 8];17(1):1–7. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2893-8
21. Salyer ACD, Caruso G, Khetani KK, Fox LM, Malladi SS, David SA. Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen. PLoS One [Internet]. 2016 Feb 1 [cited 2023 Jul 8];11(2):e0149848. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149848
22. Wiysonge CS, Ndwandwe D, Ryan J, Jaca A, Batouré O, Anya BPM, et al. Vaccine hesitancy in the era of COVID-19: could lessons from the past help in divining the future? [Internet]. 2021 [cited 2023 Jul 8];18(1):1–3. Available from: https://www.tandfonline.com/doi/abs/10.1080/21645515.2021.1893062
23. Spinewine A, Pétein C, Evrard P, Vastrade C, Laurent C, Delaere B, et al. Attitudes towards COVID‐19 vaccination among hospital staff—understanding what matters to hesitant people. Vaccines (Basel) [Internet]. 2021 May 1 [cited 2023 Jul 8];9(5):469. Available from: https://www.mdpi.com/2076-393X/9/5/469/htm
24. Vila-Candel R, Navarro-Illana P, Navarro-Illana E, Castro-Sánchez E, Duke K, Soriano-Vidal FJ, et al. Determinants of seasonal influenza vaccination in pregnant women in Valencia, Spain. BMC Public Health [Internet]. 2016 Nov 21 [cited 2023 Jul 8];16(1):1–7. Available from: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-3823-1
25. Lauria ME, Fiori KP, Jones HE, Gbeleou S, Kenkou K, Agoro S, et al. Assessing the Integrated Community-Based Health Systems Strengthening initiative in northern Togo: A pragmatic effectiveness-implementation study protocol. Implement Sci [Internet]. 2019 Oct 16 [cited 2023 Jul 8];14(1):1–13. Available from: https://implementationscience.biomedcentral.com/articles/10.1186/s13012-019-0921-3
26. Molina V, Shoenfeld Y. Infection, vaccines and other environmental triggers of autoimmunity [Internet]. 2009 May [cited 2023 Jul 8];38(3):235–45. Available from: https://www.tandfonline.com/doi/abs/10.1080/08916930500050277
27. Castellani J, Mihaylova B, Siribié M, Gansane Z, Ouedraogo AZ, Fouque F, et al. Household costs and time to treatment for children with severe febrile illness in rural Burkina Faso: The role of rectal artesunate. Malar J [Internet]. 2018 Oct 22 [cited 2023 Jul 8];17(1):1–12. Available from: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2526-8
28. Yokoe DS, Anderson DJ, Berenholtz SM, Calfee DP, Dubberke ER, Ellingson KD, et al. A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates. Infect Control Hosp Epidemiol [Internet]. 2014 Aug [cited 2023 Jul 8];35(8):967–77. Available from: https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/abs/compendium-of-strategies-to-prevent-healthcareassociated-infections-in-acute-care-hospitals-2014-updates/D614418D83367A02291BA6EB97395202
