The impact of drug related problems on health-related quality of life among hypertensive patients in Jordan


Background: Hypertension is a major cause of cardiovascular diseases with a high prevalence in Jordan. No previous studies have been carried out to determine the effect of the presence of drug-related problems (DRPs) on the health-related quality of life (HRQOL) among hypertensive patients.

Objectives: The purpose of this study was to identify the influence of different types of DRPs on the HRQOL of hypertensive patients.

Methods: A total of 200 hypertensive patients were recruited in this cross-sectional correlation study that was conducted across the cardiac outpatient clinic at Jordan University Hospital. Ethical approval was obtained and patients were recruited using convenience sampling technique. During the study period, patients’ data was used to evaluate their quality of life using RAND-12 scale and to identify DRPs utilizing a systematic evidence based approach.

Results: 200 hypertensive patients (mean age 59.7 years (SD=10.2)) were recruited in this study. Patients showed a poor quality of life on both the physical and mental domains of the RAND-12 scale. The average number of DRPs was 5.1 (SD=2.3). Multiple linear regression analysis showed that among DRPs categories, non-adherence to medications, non-adherence to non-pharmacological therapies and inadequate knowledge about medications were among the main predictors of the poor physical domain of the RAND-12 (Beta= -0.149, -0.226 and -0.230 respectively, p-value < 0.05 for all). On the other hand, only non-adherence to medication and non-adherence to non-pharmacological therapies were significantly associated with poor mental domain of the RAND-12 (Beta= -0.208 and -0.191 respectively, p-value < 0.05 for both).

Conclusion: Prevalence of DRPs among hypertensive patients is a concern that needs attention. These DRPs were associated with poor HRQOL on both the physical and mental domain of the RAND-12 scale. The pharmaceutical care service delivered by pharmacists is needed to identify, prevent and resolve DRPs, which may improve patients HRQOL.


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How to Cite
ABU FARHA, Rana; SALEH, Akram; ABURUZ, Salah. The impact of drug related problems on health-related quality of life among hypertensive patients in Jordan. Pharmacy Practice, [S.l.], v. 15, n. 3, p. 995, sep. 2017. ISSN 1886-3655. Available at: <>. Date accessed: 17 oct. 2017.
Original Research


Hypertension; Quality of Life; Medication Errors; Patient Medication Knowledge; Medication Adherence; Risk Factors; Regression Analysis; Cross-Sectional Studies; Jordan