Medication reconciliation at patient admission: a randomized controlled trial

  • Antonio E. Mendes
  • Natália F. Lombardi
  • Vânia M. Andrzejevski
  • Gibran Frandoloso
  • Cassyano J. Correr
  • Maurício Carvalho
Keywords: Medication Reconciliation, Pharmaceutical Services, Randomized Controlled Trials as Topic, Brazil

Abstract

Objective: To measure length of hospital stay (LHS) in patients receiving medication reconciliation. Secondary characteristics included analysis of number of preadmission medications, medications prescribed at admission, number of discrepancies, and pharmacists interventions done and accepted by the attending physician.

Methods: A 6 month, randomized, controlled trial conducted at a public teaching hospital in southern Brazil. Patients admitted to general wards were randomized to receive usual care or medication reconciliation, performed within the first 72 hours of hospital admission.

Results: The randomization process assigned 68 patients to UC and 65 to MR. LHS was 10±15 days in usual care and 9±16 days in medication reconciliation (p=0.620). The total number of discrepancies was 327 in the medication reconciliation group, comprising 52.6% of unintentional discrepancies. Physicians accepted approximately 75.0% of the interventions.

Conclusion: These results highlight weakness at patient transition care levels in a public teaching hospital. LHS, the primary outcome, should be further investigated in larger studies. Medication reconciliation was well accepted by physicians and it is a useful tool to find and correct discrepancies, minimizing the risk of adverse drug events and improving patient safety.

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Author Biographies

Antonio E. Mendes

Internal Medicine Department - Clinical Pharmacy Service

RPh, Pharmacist 

Natália F. Lombardi

Pharmaceutical Sciences Department

RPh, Pharmacist

Vânia M. Andrzejevski

Clinics Hospital - Hospital Pharmacy Unit

RPh, Pharmacist

Gibran Frandoloso

Internal Medicine Department

MD, Auxiliar Professor 

Cassyano J. Correr

Pharmaceutical Sciences Department

Pharm PhD, Adjunct Professor 

Maurício Carvalho

Internal Medicine Department

MD PhD, Adjunct Professor 

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Published
2016-03-12
How to Cite
1.
Mendes AE, Lombardi NF, Andrzejevski VM, Frandoloso G, Correr CJ, Carvalho M. Medication reconciliation at patient admission: a randomized controlled trial. Pharm Pract (Granada) [Internet]. 2016Mar.12 [cited 2019Jun.27];14(1). Available from: https://www.pharmacypractice.org/journal/index.php/pp/article/view/656
Section
Original Research

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