Positive and Negative Syndrome Scale as a long-term outcome measurement tool in patients receiving clozapine ODT- A Pilot Study

  • Gollapudi Shankar
  • Carmen Nate
Keywords: Antipsychotic Agents, Quality of Life, Treatment Outcome, United States

Abstract

Objective: This pilot, twelve-week, open-label study examined the effect of clozapine orally disintegrating tablet or ODT in patients with schizophrenia and schizoaffective disorder utilizing Positive and Negative Syndrome Scale (PANSS) as a long-term outcome measurement tool.

Methods: The final study sample consisted of nineteen subjects who were residents a long-term care psychiatric facility in Pomona, California.  Subjects were using clozapine ODT (FazaClo®) at the most clinically effective dosage depending on their symptoms and at the discretion of the psychiatrist and psychopharm consultant. PANSS were administered at baseline, week-4, week-8 and week-12. Paired sample t-tests were used to calculate the statistical significance of the mean differences for scores at baseline and week-12.

Results: Mean differences from baseline indicated significant improvement on total score, as well as positive, negative, cognitive and general psychopathology subscales after twelve weeks of treatment. The greater average reduction in the negative syndrome subscale across the twelve weeks possibly illustrates the ability of clozapine ODT in improving negative symptoms, including cognitive function which is their ability to participate in their personal care and creative expressions in dance, arts, games, poetry to a greater extent their overall, quality of life and living along with the effect on positive symptoms.

Conclusion: Overall, clozapine proved to affect a broad range of psychopathology including cognitive functions in this schizophrenic sample.

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References

1. Lexi-Comp. UpToDate®: “Clozapine: Drug information.”.

2. Alamo Pharmaceuticals. FazaClo® General Information. http://www.fazaclo.com/GeneralInfo.asp. (Accessed 03/02/2006).

3. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987; 2:261-276.

4. Lindenmayer J, Grochowski S, Mabugat L. Clozapine effects on Positive and Negative Symptoms: A six-month trial in treatment-refractory schizophrenics. J Clin Psychopharmacol 1994; 14:201-4.

5. Volavka J, Czobor P, Sheitman B, Lindenmayer J, Citrome L, McEvoy JP, Cooper TB, Chakos M, Lieberman JA. Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder. Am J Psychiatry 2002; 159:255-62
Published
2007-04-02
Section
Original Research