Assessment of prescription profile of pregnant women visiting antenatal clinics

  • Uchenna I. Eze
  • Adego E. Eferakeya
  • Azuka C. Oparah
  • Ehijie F. Enato
Keywords: Teratogens, Pregnancy, Maternal Exposure, Nigeria

Abstract

Managing medical complications in pregnancy is a challenge to clinicians.

Objectives: This study profiled some disease and prescription patterns for pregnant women attending antenatal clinics (ANCs) in Nigeria. A risk classification of the medicines was also determined.

Methods: Medical case files of 1,200 pregnant women attending antenatal clinics of 3 health facilities in Benin City, Nigeria were investigated.  Disease pattern was determined from their diagnoses. The prescription pattern was assessed using WHO indicators, and the United States Food and Drug Administration classification of medicines according to risk to the foetus.

Results: A total of 1,897 prescriptions of the 1,200 pregnant women attendees during the period under review were evaluated. Results indicated that malaria 554 (38%) was the most prevalent disease, followed by upper respiratory tract infections (URTIs, 13%) and gastrointestinal disturbances (GIT, 12%). The average number of drugs prescribed per encounter was found to be 3.0, and 2,434 (43%) of medicines were prescribed by generic name. Minerals/ Vitamins 2,396 (42%) were the most frequently prescribed medicines, and antibiotics occurred in 502 (8.8%) of the total medicines. Of all medicines prescribed, 984 (17%) were included in the foetal risk category C and 286 (5%) in category D.

Conclusion: The study concluded that malaria fever occurred most frequently followed by URTIs and GIT disturbances among the pregnant women. Minerals, vitamins and to a less extent anti-malarials topped the list of the prescribed medicines. The average number of medicines per encounter was much higher than WHO standards. The occurrence of contraindicated medicines was low.

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References

1. Cheney BE. Management of common primary care problems during pregnancy. Program and abstracts of the 5th Annual Conference of the National Association of Nurses Practitioners in women’s health. September 27-29, 2002 Scottsdale Arizona.

2. Vallance P. Drugs and the foetus. BMJ 1996;312:1053-4.

3. Banhidy F, Lowry BR, Czeizel AE. Risk and benefit of drug use during pregnancy. Int J Med Sci. 2005;2(3):100-6.

4. Webster WS, Freeman JA. Prescription drugs and pregnancy. Expert Opin Pharmacother 2003; 4(6): 949-61.

5. Revan VB, Sun ET, Morris MC. Management of asthma in pregnancy. Female Patient 2002:27;18-28.

6. Young VSL.Teratogenicity and Drugs in the breast milk. In: Koda kimble, MA. et al. eds. Applied Therapeutics: The Clinical Use of Drugs 7th edition USA Lippincott Williams & Wilkins; 2001.

7. Das B, Sarkar C, Datta A, Bohra S. A study of drug use during pregnancy in a Teaching Hospital in Western Nepal. Pharmacoepidemiol Drug Saf 2003; 12(3):221-5.

8. Collabourative Group on Drug Use in Pregnancy. An international survey on drug utilization. Int J Risk Safety Med 1991; 1:1.

9. Odusanya OO, Oyediran MA. Rational drug use at primary health care centers in Lagos, Nigeria. Nig Qt J Hosp Med 2000;10:4-7.

10. Gharoro EP, Igbafe AA. Pattern of drug use amongst antenatal patients in Benin City, Nigeria. Med Sci Monit, 2000; 6 (1);84-87.

11. How to investigate drug use in health facilities: selected drug use indicators. Action Programme on Essential Drugs. (WHO/DAP/(93.1) Geneva, World Health Organization, 1985.

12. Carmo TA, Nitrini SM. Prescricoes de medicamentos para gestantes: um estudo farmacoepidemiologico. Cad Saude Publica 2004;20(4):1004-13.

13. Kelly WJ. Physician’s drug hand book 10th edition, Philadelphia: Lippincott Williams & Wilkins; 2003.

14. World Health Organization (WHO/AFRO). A strategic framework for malaria prevention and control during pregnancy in the African region. World Health Organization Regional Office for Africa, Brazzaville – AFR/MAL/04.01; 2004.

15. Enato EF, Okhamafe AO, Okpere EE. A survey of knowledge, attitude and practice of malaria management among pregnant women from two health care facilities in Nigeria. Acta Obstet Gynecol Scand. 2007;86:33-6.

16. Enato EF, Okhamafe AO, Okpere EE, Oseji FI. Prevalence of malaria during pregnancy and antimalarial intervention in an urban secondary health care facility in Southern Nigeria. Med Prin Pract 2007;16:240-3.

17. Krause G, Borchert M, Benzler J, Heinmuller R, Kaba I, Savadogo M, Siho N, Diesfeld HJ. Research report. Rationality of drug prescriptions in rural health centers in Burkina Faso. Health Policy Plan 1999;14:291-8.

18. Gracia I, Beyens MN, Gauchoux R, Guy C, Ollagnier M. Drug Prescription for pregnant women in the Department of the Loire. Therapie. 2000; 55(5):605-11.

19. Mengue SS, Schenkel EP, Duncan BB, Schmidt MI. Uso de medicamentos por gestantes em seis cidades brasileiras. Rev Saude Publica 2001; 35(5) :415-20.

20. Beyens MN, Guy C, Ratrema M, Ollagnier M. Prescription of drugs to pregnant women in France. The HIMAGE study. Therapie 2003; 558(6): 505-11.
Published
2007-09-10
Section
Original Research

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