The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled study


Background: Poor adherence to antidiabetic medications leads to a higher rate of hospital admissions and adverse health outcomes in type 2 diabetes mellitus patients.

Objective: This study aims to evaluate whether a pharmacist-led medication therapy management, compared to the usual care, could enhance medication adherence and reduce hospital admission in patients with type 2 diabetes mellitus.

Methods: A prospective randomized controlled study was conducted in patients with type 2 diabetes mellitus from February 1 to July 30, 2016. Patients in the control group (n=65) received the usual care while patients in the intervention group (n=62) received a personalized pharmacotherapeutic care plan and diabetes education. The two groups were compared by repeated measure ANOVA at 3 and 6‐months with medication adherence (using Morisky medication adherence scale) and number of hospital admissions as the main outcome variables.

Results: A total of 127 patients were included in the study. A marked and statistically significant increase in medication adherence from baseline to 3 and 6 months were noted in the intervention group (increased from 9.2% at baseline to 61% at 6 month) compared with the control group (increased from 13.2% at baseline (to 30.2% at 6 month; p-value<0.01). Furthermore, at the 6-month follow-up, only 23 patients in MTM group with poorly controlled blood glucose levels resulted in hospital admissions compared to 48 patients in non-MTM group, resulting in a 52.1% fewer hospital admissions (p< 0.001).

Conclusions: The findings of this study implied that pharmacist-led medication therapy management might improve medication adherence and reduce number of hospitalizations in patients with type 2 diabetes mellitus. Hence, policies and guidelines should be in place in order for clinical pharmacists to fully engage in patient care and improve the medication therapy outcomes.


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Author Biographies

Daniel A. Erku

Department of clinical pharmacyy, Lecturer

Asnakew A. Ayele
Department of clinical pharmacy, Lecturer
Abebe B. Mekuria
Department of pharmacology, Lecturer
Sewunet A. Belachew
Department of clinical pharmacy
Bisrat Hailemeskel
school of pharmacy, Associate professor
Henok G. Tegegn
department of clinical pharmacy, Assistant professor


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How to Cite
ERKU, Daniel A. et al. The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled study. Pharmacy Practice, [S.l.], v. 15, n. 3, p. 1026, sep. 2017. ISSN 1886-3655. Available at: <>. Date accessed: 17 oct. 2017.
Original Research


Diabetes Mellitus, Type 2; Medication Therapy Management; Medication Adherence; Pharmacists; Treatment Outcome; Patient Education as Topic; Ethiopia

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