Assessment of commitment to healthy daily habits and diets, preventive measures, and beliefs about natural products utilization during COVID-19 pandemic in certain population in Egypt and Saudi Arabia
Main Article Content
Keywords
Coronavirus, COVID-19, Questionnaire , Natural food and drinks, Egypt, Saudi Arabia
Abstract
<p style="text-align: justify;"><strong>Objective: </strong>The purpose of this research is to assess the commitment of participants in Saudi Arabia and Egypt towards healthy daily habits, preventive measures, healthy food habits, and beliefs about natural products as an immunostimulants during COVID-19 pandemic. <strong>Method: </strong>A cross-sectional questionnaire-based study was conducted in Saudi Arabia (mainly Riyadh and Jeddah) and Egypt (mainly Cairo). The questionnaire instrument was created based on an extensive literature review on the COVID-19 pandemic, including its spreading and transmission methods, preventive measures, healthy lifestyle, and diets that increase human immunity against viral infections and the use of natural products and drinks. The questionnaire was created by Microsoft 365® office forms, participants were invited through emails and other social media. The questionnaire includes a demographic section (gender, nationality, residency country, city, age, marital status, educational level, employment status, chronic disease history, under anxiety or stress, have a temper or irritable person, were infected/currently infected and in contact to COVID-19 patient) and (23) questions arranged under five domains; Domain I daily habits (4), Domain II keeping preventive measures (4), Domain III healthy eating habits (9), Domain IV for participants currently or previously infected, or in contact with a patient (4) Domain V for assessment of participants’ beliefs towards the use of natural products to elevate immunity during COVID-19 pandemic (2), beside 4 choice questions (stimulant drinks, natural drinks, natural products, and zinc-rich food). SPSS® was used to analyze the results using Student’ t-test, ANOVA, and Tukey’s HSD tests.<strong> Result:</strong> 510 individuals with various demographic characteristics participated in the study. This study revealed that the participants belief in healthy foods, natural drinks (mainly ginger, lemon, and cinnamon), natural products (mainly honey, olive oil, and black seed), healthy habits, and preventive measures as sanitizers, social distance, and exercise. Only 13% of all participants were infected with COVID-19, although 31% of them were in contact with COVID -19 patients, about 93% were under stress, and 22% were with chronic diseases. Participants who are married, not in contact with patients and not previously infected by COVID-19 are more adhered to preventive measures while those previously or currently infected are more committed to healthy lifestyle and diet habits. Qualification level seems to make no significant difference in any domain. 78.6% of the participants beliefs in the benefits of utilizing natural products in preventing infection with corona virus or reducing the period of treatment in case of infection. About 95.7% of the infected persons had no need of hospitalization and about 50% are cured within two weeks of infection. The questionnaire revealed that Nescafe and black tea were the most used stimulant drinks among the participants, particularly the students and who were always under stress. Most of the participants agreed with the utilization of Zn-rich food, particularly Egyptians, which may help in boosting their immunity. <strong>Conclusion:</strong> Natural products selected in the present study can be used in combination with the existing clinical standards of care that have the potential to serve as prophylactic agents in populations that are at risk to develop COVID-19 infection.</p>
References
1. World Health Organization WHO supports scientifically-proven traditional medicine; 2020.
2. Shahwar D, Raza MA, Shafiq-U, et al. An investigation of phenolic compounds from plant sources as trypsin inhibitors. Natural Product Research. 2012;26(12):1087-1093. https://doi.org/10.1080/14786419.2011.559637
3. Parhiz H, Roohbakhsh A, Soltani F, et al. Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An updated review of their molecular mechanisms and experimental models: hesperidin and hesperetin as
antioxidant and anti-inflammatory agents. Phytother Res. 2015;29(3):323-331. https://doi.org/10.1002/ptr.5256
4. Gopalakrishnan S, Ediga HH, Reddy SS, et al. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells: PCB2 from cinnamon acts as a proteasome inhibitor. IUBMB Life.2018;70(5):445-457. https://doi.org/10.1002/iub.1735
5. Szakiel A, Czkowski CP, Pense F, et al. Fruit cuticular waxes as a source of biologically active triterpenoids. Phytochem Rev.
2012;11(2-3):263-284. https://doi.org/10.1007/s11101-012-9241-9
6. Cazzoletti L, Zanolin ME, Spelta F, et al. Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study. Clin Exp Allergy. 2019;49(6):799-807. https://doi.org/10.1111/cea.13352
7. Li J, Ye L, Wang X, et al. Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells. J Neuroinflammation. 2012;9:579. https://doi.org/10.1186/1742-2094-9-161
8. Heinrich M, Mah J, Amirkia V. Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look. Molecules. 2021;26(7):1836.
9. Lake MA. What we know so far: COVID-19 current clinical knowledge and research. Clin Med. 2020;20(2):124-127. https://doi.org/10.7861/clinmed.2019-coron
10. Zhanga Y, Gengb X, Tan Y, et al. New understanding of the damage of SARS-CoV-2 infection outside therespiratory system.Biomedicine & Pharmacotherapy. 2020;127:110195. https://doi.org/10.1016/j.biopha.2020.110195
11. Aygün İ, Kaya M, Alhajj R. Identifying side efects of commonly used drugs in the treatment of Covid 19. Scientific Reports.2020;10:21508.
12. Salath M, Althaus CL, Neher R, et al. COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation. Swiss Med Wly. 2020. https://doi.org/10.4414/smw.2020.20225
13. World Health Organization Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19); 2019.
14. Luo H, Tang Q, Shang Y, et al. Can chinese medicine be used for prevention of corona virus disease 2019 (covid-19)? a review
of historical classics, research evidence and current prevention programs. Chin J Integr Med. 2020;26(4):243-250. https://doi.org/10.1007/s11655-020-3192-6
15. Khanna K, Kohli SK, Kaur R, et al. Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle. Phytomedicine.2021;85:153361. https://doi.org/10.1016/j.phymed.2020.153361
16. Al Najrany SM, Asiri Y, Sales I, et al. The Commonly Utilized Natural Products during the COVID-19 Pandemic in Saudi Arabia: A Cross-Sectional Online Survey. IJERPH. 2021;18(9):4688. https://doi.org/10.3390/ijerph18094688
17. World Health Organization WHO supports scientifically proven traditional medicine; 2020.
18. Centers for Disease Control and Prevention When and How to Wash Your Hands. 2020.
19. Central Agency for Public Mobilization and Statistics. https://www.capmas.gov.eg/homepage.aspx. Accessed 22 September2021.
20. General Authority for Statistics. https://database.stats.gov.sa/beta/dashboard/landing. Accessed 22 September 2021.
21. Suardi C, Cazzaniga E, Graci S, et al. Link between Viral Infections, Immune System, Inflammation and Diet. IJERPH. 2021;18(5):2455. https://doi.org/10.3390/ijerph18052455
22. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. The Lancet. 2020;395(10229):1033-1034. https://doi.org/10.1016/S0140-6736(20)30628-0
23. Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. Journal of Clinical Investigation. 2020;130(5):2202-2205. https://doi.org/10.1172/JCI137647
24. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020;38(1):1-9. https://doi.org/10.12932/AP-200220-0772
25. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
26. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(102230:507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
27. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062, https://doi.org/10.1016/S0140-6736(20)30566-3
28. Vatic M, von Haehling S, Ebner N. Inflammatory biomarkers of frailty. Experimental Gerontology. 2020;133:110858. https://doi.org/10.1016/j.exger.2020.110858
29. Kamp G, Kramer A. Epidemiologic Background of Hand Hygiene and Evaluation of the Most Important Agents for Scrubs and Rubs. Clin Microbiol Rev. 2004;17(4):863-893, https://doi.org/10.1128/CMR.17.4.863-893.2004.30
30. World Health Organization Report of the WHO, Advice for the public: Coronavirus disease (COVID-19). 2022.
31. Dizdar O, Baspınar O, Kocer D, et al. Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic. Nutrients. 2016;8(3):124. https://doi.org/10.3390/nu8030124
32. Aman F, Masood S. How nutrition can help to fight against COVID-19 pandemic. Pak J Med Sci. 2020;36(COVID19-S4):S121-S123. https://doi.org/10.12669/pjms.36.COVID19-S4.2776
33. Cena H, Chieppa M. Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection? Front Immunol. 2020;11:944. https://doi.org/10.3389/fimmu.2020.00944
34. Kumar V, Singh S, Srivastava B, et al. Green synthesis of silver nanoparticles using leaf extract of Holoptelea integrifolia and preliminary investigation of its antioxidant, anti-inflammatory, antidiabetic and antibacterial activities. Journal of EnvironmentalChemical Engineering. 2019;7:103094. https://doi.org/10.1016/j.jece.2019.103094
35. Fiore C, Eisenhut M, Krausse R, et al. Antiviral effects of Glycyrrhiza species. Phytother Res. 2008;22(2):141-148. https://doi.org/10.1002/ptr.2295
36. Chang JS, Wang KC, Yeh CF, et al. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytialvirus in human respiratory tract cell lines. Journal of Ethnopharmacology. 2013;145(1):146-151. https://doi.org/10.1016/j.jep.2012.10.043
37. Li J, Ye L, Wang X, et al. Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in humancerebral microvascular endothelial cells. J Neuroinflammation. 2012;9:579. https://doi.org/10.1186/1742-2094-9-161
38. Horrigan LA, Kelly JP, Connor TJ. Caffeine suppresses TNF-α production via activation of the cyclic AMP/protein kinase A pathway. International Immunopharmacology. 2004;4(10-11):1409-1417. https://doi.org/10.1016/j.intimp.2004.06.005
39. Horriga L, Kelly J, Connor T. Immunomodulatory effects of caffeine: Friend or foe? Pharmacology & Therapeutics. 2006;111:877-892. https://doi.org/10.1016/j.pharmthera.2006.02.002
40. Erickson KL, Medina EA, Hubbard NE. Micronutrients and Innate Immunity. J Infect Dis. 2000;182:S5-S10. https://doi.org/10.1086/315922
41. Wang Y, Li J, Wang X, et al. Epigallocatechin-3-Gallate Enhances Hepatitis C Virus Double-Stranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes. Sci Rep. 2016;6:21595. https://doi.org/10.1038/srep21595
42. McKechnie JL, Blish CA. The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19? Cell Host & Microbe. 2020;27(6):863-869. https://doi.org/10.1016/j.chom.2020.05.009
43. Chowdhury P, Barooah AK. Tea Bioactive Modulate Innate Immunity: In Perception to COVID-19 Pandemic. Front Immunol.2020;11:590716. https://doi.org/10.3389/fimmu.2020.590716
44. Bao S, Liu MJ, Lee B, et al. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2010;298(6):L744-754. https://doi.org/10.1152/ajplung.00368.2009
45. Dizdar O, Baspınar O, Kocer D, et al. Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic. Nutrients. 2016;8(3):124. https://doi.org/10.3390/nu8030124
46. Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017;9(12):1286. https://doi.org/10.3390/nu9121286
47. Lee SM, McLaughlin JN, Frederick DR, et al. Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.Am J Physiol Lung Cell Mol Physiol. 2013;304(5):L350-360. https://doi.org/10.1152/ajplung.00243.2012
48. Iddir M, Brito A, Dingeo G, et al. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020;12(6):1562. https://doi.org/10.3390/nu12061562
49. Grant W, Lahore H, McDonnell S, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. https://doi.org/10.3390/nu12040988
50. Mao QQ, Xu XY, Cao SY, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. 019;8(6):185.https://doi.org/10.3390/foods8060185
51. Rodrigues FA, Santos AD, de Medeiros PHQS, et al. Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production. Sci Rep. 2018;8(1):12154. https://doi.org/10.1038/s41598-018-30522-6
52. Idris NA, Yasin HM, Usman A. Voltammetric and spectroscopic determination of polyphenols and antioxidants in ginger(Zingiber officinale Roscoe). Heliyon. 2019;5(5):e01717. https://doi.org/10.1016/j.heliyon.2019.e01717
53. Shariatpanahi ZV, Mokhtari M, Taleban FA, et al. Effect of enteral feeding with ginger extract in acute respiratory distress syndrome. Journal of Critical Care. 2013;28(2):217.e1-217.e6. https://doi.org/10.1016/j.jcrc.2012.04.017
54. Liao YR, Leu YL, Chan YY, et al. Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale. Molecules. 2012;17(8):8928-8937. https://doi.org/10.3390/molecules17088928
55. Klimek-Szczykutowicz, Szopa. Ekiert Citrus limon (Lemon) Phenomenon—A Review of the Chemtry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies. Plants.2020;9(1):119. https://doi.org/10.3390/plants9010119
56. Chambial S, Dwivedi S, Shukla KK, et al. Vitamin C in Disease Prevention and Cure: An Overview. Ind J Clin Biochem.
2013;28(4):314-328. https://doi.org/10.1007/s12291-013-0375-3
57. Hong JY, Lee CY, Lee MG, et al. Effects of dietary antioxidant vitamins on lung functions according to gender and smoking status in Korea: a population-based cross-sectional study. BMJ Open. 2018;8(4):e020656. https://doi.org/10.1136/bmjopen-2017-020656
58. Fisher BJ, Kraskauskas D, Martin EJ, et al. Attenuation of Sepsis-Induced Organ Injury in Mice by Vitamin C. JPEN J Parenter Enteral Nutr. 2014;38(7):825-839. https://doi.org/10.1177/0148607113497760
59. Carr A, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9:1211. https://doi.org/10.3390/nu9111211
60. Rodrigues FA, Santos AD, de Medeiros PHQS, et al. Gingerol suppresses sepsis-induced acute kidney injury by modulatingmethylsulfonylmethane and dimethylamine production. Sci Rep. 2018;8(1):12154. https://doi.org/10.1038/s41598-018-30522-6
61. Jayaprakasha GK, Rao LJM. Chemistry, Biogenesis, and Biological Activities of Cinnamomum zeylanicum. Critical Reviews in Food Science and Nutrition. 2011;51(6):547-562. https://doi.org/10.1080/10408391003699550
62. Rao PV, Gan SH. Cinnamon: A Multifaceted Medicinal Plant. Evidence-Based Complementary and Alternative Medicine. 2014;2014:1-12. https://doi.org/10.1155/2014/642942
63. Zhuang M, Jiang H, Suzuki Y, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Research. 2009;82(1):73-81. https://doi.org/10.1016/j.antiviral.2009.02.001
64. Simmons G, Bertram S, Glowacka I, et al. Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion. Virology. 2011;413(2):265-274. https://doi.org/10.1016/j.virol.2011.02.020
65. Shahzad A, Cohrs RJ. In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles. Transl Biomed. 2012;3(2):2. https://doi.org/10.3823/434
66. Watanabe K, Rahmasari R, Matsunaga A, et al. Anti-influenza Viral Effects of Honey In Vitro: Potent High Activity of Manuka Honey. Archives of Medical Research. 2014;45(5):359-365. https://doi.org/10.1016/j.arcmed.2014.05.006
67. Chua LS, Abdul-Rahaman NL, Sarmidi MR, et al. Multi-elemental composition and physical properties of honey samples from Malaysia. Food Chemistry. 2012;135(3):880-887. https://doi.org/10.1016/j.foodchem.2012.05.106
68. Dong C, Li X, Song Q, et al. Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19).Infectious Diseases (except HIV/AIDS). 2020.
69. Sulaiman SA, Hasan H, Deris ZZ, et al. The Benefit of Tualang Honey in Reducing Acute Respiratory Symptons Among Malaysian Hajj Pilgrims: A Preliminary Study. J Api Prod Api Med Sci. 2011;3:38-44. https://doi.org/10.3896/IBRA.4.03.1.07
70. Hashem H. In Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors; Chemistry. 2020.
71. Hossain KS, Hossain MG, Moni A, et al. Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises. Heliyon. 2020;6(12):e05798. https://doi.org/10.1016/j.heliyon.2020.e05798
72. Aparicio-Soto M, Sánchez-Hidalgo M, Rosillo MÁ, et al. Extra virgin olive oil: a key functional food for prevention of immuneinflammatory
diseases. Food Funct. 2016;7(11):4492-4505. https://doi.org/10.1039/C6FO01094F
73. Bonura A, Vlah S, Longo A, et al. Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects. Immunobiology. 2016;221(12):1374-1377. https://doi.org/10.1016/j.imbio.2016.07.009
74. Casas R, Estruch R, Sacanella E. The Protective Effects of Extra Virgin Olive Oil on Immune-mediated Inflammatory Responses.EMIDDT. 2017;18(1):23-35. https://doi.org/10.2174/1871530317666171114115632
75. Gambino CM, Accardi G, Aiello A, et al. Effect of Extra Virgin Olive Oil and Table Olives on the ImmuneInflammatory Responses:Potential Clinical Applications. EMIDDT. 2017;18(1):14-22. https://doi.org/10.2174/1871530317666171114113822
76. Majumder D, Debnath M, Sharma KN, et al. Olive oil consumption can prevent non-communicable diseases and COVID-19:Review. CPB. 2022;23(2):261-275. https://doi.org/10.2174/1389201022666210412143553
77. Maideen NMP. Prophetic Medicine-Nigella Sativa (Black cumin seeds) - Potential herb for COVID-19? J Pharmacopuncture.2020;23(2):62-70. https://doi.org/10.3831/KPI.2020.23.010
78. Islam MN, Hossain KS, Sarker PP, et al. Revisiting pharmacological potentials of NIGELLA SATIVA seed: A promising option forCOVID ‐19prevention and cure. Phytotherapy Research 2021;35(3):1329-1344. https://doi.org/10.1002/ptr.6895
79. Bouchentouf S, Missoum N. Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): Molecular Docking Study, Chemistry. 2020.
80. Menon VP, Sudheer AR. Antioxidant and Anti-inflammatory Properties of Curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Advances in Experimental Medicine and Biology; Springer US: Boston, MA.
2007;595:105-125.
81. Srivastava RM, Singh S, Dubey SK, et al. Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology. 2011;11:331-341. https://doi.org/10.1016/j.intimp.2010.08.014
82. Avasarala S, Zhang F, Liu G, et al. Curcumin Modulates the Inflammatory Response and Inhibits Subsequent Fibrosis in a Mouse Model of Viral-induced acute respiratory distress syndrome. PLoS ONE. 2013;8(2):e57285. https://doi.org/10.1371/journal. pone.0057285
83. Hosseini A, Rasaie D, Soleymani Asl S, et al. Evaluation of the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure to paraquat in rats. Toxin Reviews. 2019;1-9. https://doi.org/10.1080/15569543.2019.
1675707
84. Chen H, Yang R, Tang Y, et al. Effects of curcumin on pulmonary fibrosis and functions of paraquat-challenged rats. 2017;29(11):973-976. https://doi.org/10.3760/cma.j.issn.2095-4352.2017.11.003
85. Gautam SC, Gao X, Dulchavsky S. Immunomodulation by Curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Springer US: Boston, MA. 2007;595:321-341.
86. WHO monographs on selected medicinal plants; World Health Organization, Ed.; World Health Oganization: Geneva; 1999.
87. Santiago de Chile; Ministerio de Salud MHT: traditional herbal medicines: 103 plant species. 2010.
88. Kuete V. Thymus vulgaris. In Medicinal Spices and Vegetables from Africa; Elsevier. 2017;599609.
89. Salehi B, Abu-Darwish MS, Tarawneh AH, et al. Thymus spp. plants - Food applications and phytopharmacy properties. Trends in Food Science and Technology. 2019;85:287-306. https://doi.org/10.1016/j.tifs.2019.01.020
90. Nolkemper S, Reichling J, Stintzing FC, et al. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta Med. 2006;72(15):1378-1382. https://doi.org/10.1055/s-2006-951719
2. Shahwar D, Raza MA, Shafiq-U, et al. An investigation of phenolic compounds from plant sources as trypsin inhibitors. Natural Product Research. 2012;26(12):1087-1093. https://doi.org/10.1080/14786419.2011.559637
3. Parhiz H, Roohbakhsh A, Soltani F, et al. Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An updated review of their molecular mechanisms and experimental models: hesperidin and hesperetin as
antioxidant and anti-inflammatory agents. Phytother Res. 2015;29(3):323-331. https://doi.org/10.1002/ptr.5256
4. Gopalakrishnan S, Ediga HH, Reddy SS, et al. Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells: PCB2 from cinnamon acts as a proteasome inhibitor. IUBMB Life.2018;70(5):445-457. https://doi.org/10.1002/iub.1735
5. Szakiel A, Czkowski CP, Pense F, et al. Fruit cuticular waxes as a source of biologically active triterpenoids. Phytochem Rev.
2012;11(2-3):263-284. https://doi.org/10.1007/s11101-012-9241-9
6. Cazzoletti L, Zanolin ME, Spelta F, et al. Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study. Clin Exp Allergy. 2019;49(6):799-807. https://doi.org/10.1111/cea.13352
7. Li J, Ye L, Wang X, et al. Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells. J Neuroinflammation. 2012;9:579. https://doi.org/10.1186/1742-2094-9-161
8. Heinrich M, Mah J, Amirkia V. Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look. Molecules. 2021;26(7):1836.
9. Lake MA. What we know so far: COVID-19 current clinical knowledge and research. Clin Med. 2020;20(2):124-127. https://doi.org/10.7861/clinmed.2019-coron
10. Zhanga Y, Gengb X, Tan Y, et al. New understanding of the damage of SARS-CoV-2 infection outside therespiratory system.Biomedicine & Pharmacotherapy. 2020;127:110195. https://doi.org/10.1016/j.biopha.2020.110195
11. Aygün İ, Kaya M, Alhajj R. Identifying side efects of commonly used drugs in the treatment of Covid 19. Scientific Reports.2020;10:21508.
12. Salath M, Althaus CL, Neher R, et al. COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation. Swiss Med Wly. 2020. https://doi.org/10.4414/smw.2020.20225
13. World Health Organization Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19); 2019.
14. Luo H, Tang Q, Shang Y, et al. Can chinese medicine be used for prevention of corona virus disease 2019 (covid-19)? a review
of historical classics, research evidence and current prevention programs. Chin J Integr Med. 2020;26(4):243-250. https://doi.org/10.1007/s11655-020-3192-6
15. Khanna K, Kohli SK, Kaur R, et al. Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle. Phytomedicine.2021;85:153361. https://doi.org/10.1016/j.phymed.2020.153361
16. Al Najrany SM, Asiri Y, Sales I, et al. The Commonly Utilized Natural Products during the COVID-19 Pandemic in Saudi Arabia: A Cross-Sectional Online Survey. IJERPH. 2021;18(9):4688. https://doi.org/10.3390/ijerph18094688
17. World Health Organization WHO supports scientifically proven traditional medicine; 2020.
18. Centers for Disease Control and Prevention When and How to Wash Your Hands. 2020.
19. Central Agency for Public Mobilization and Statistics. https://www.capmas.gov.eg/homepage.aspx. Accessed 22 September2021.
20. General Authority for Statistics. https://database.stats.gov.sa/beta/dashboard/landing. Accessed 22 September 2021.
21. Suardi C, Cazzaniga E, Graci S, et al. Link between Viral Infections, Immune System, Inflammation and Diet. IJERPH. 2021;18(5):2455. https://doi.org/10.3390/ijerph18052455
22. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. The Lancet. 2020;395(10229):1033-1034. https://doi.org/10.1016/S0140-6736(20)30628-0
23. Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. Journal of Clinical Investigation. 2020;130(5):2202-2205. https://doi.org/10.1172/JCI137647
24. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020;38(1):1-9. https://doi.org/10.12932/AP-200220-0772
25. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
26. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(102230:507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
27. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062, https://doi.org/10.1016/S0140-6736(20)30566-3
28. Vatic M, von Haehling S, Ebner N. Inflammatory biomarkers of frailty. Experimental Gerontology. 2020;133:110858. https://doi.org/10.1016/j.exger.2020.110858
29. Kamp G, Kramer A. Epidemiologic Background of Hand Hygiene and Evaluation of the Most Important Agents for Scrubs and Rubs. Clin Microbiol Rev. 2004;17(4):863-893, https://doi.org/10.1128/CMR.17.4.863-893.2004.30
30. World Health Organization Report of the WHO, Advice for the public: Coronavirus disease (COVID-19). 2022.
31. Dizdar O, Baspınar O, Kocer D, et al. Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic. Nutrients. 2016;8(3):124. https://doi.org/10.3390/nu8030124
32. Aman F, Masood S. How nutrition can help to fight against COVID-19 pandemic. Pak J Med Sci. 2020;36(COVID19-S4):S121-S123. https://doi.org/10.12669/pjms.36.COVID19-S4.2776
33. Cena H, Chieppa M. Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection? Front Immunol. 2020;11:944. https://doi.org/10.3389/fimmu.2020.00944
34. Kumar V, Singh S, Srivastava B, et al. Green synthesis of silver nanoparticles using leaf extract of Holoptelea integrifolia and preliminary investigation of its antioxidant, anti-inflammatory, antidiabetic and antibacterial activities. Journal of EnvironmentalChemical Engineering. 2019;7:103094. https://doi.org/10.1016/j.jece.2019.103094
35. Fiore C, Eisenhut M, Krausse R, et al. Antiviral effects of Glycyrrhiza species. Phytother Res. 2008;22(2):141-148. https://doi.org/10.1002/ptr.2295
36. Chang JS, Wang KC, Yeh CF, et al. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytialvirus in human respiratory tract cell lines. Journal of Ethnopharmacology. 2013;145(1):146-151. https://doi.org/10.1016/j.jep.2012.10.043
37. Li J, Ye L, Wang X, et al. Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in humancerebral microvascular endothelial cells. J Neuroinflammation. 2012;9:579. https://doi.org/10.1186/1742-2094-9-161
38. Horrigan LA, Kelly JP, Connor TJ. Caffeine suppresses TNF-α production via activation of the cyclic AMP/protein kinase A pathway. International Immunopharmacology. 2004;4(10-11):1409-1417. https://doi.org/10.1016/j.intimp.2004.06.005
39. Horriga L, Kelly J, Connor T. Immunomodulatory effects of caffeine: Friend or foe? Pharmacology & Therapeutics. 2006;111:877-892. https://doi.org/10.1016/j.pharmthera.2006.02.002
40. Erickson KL, Medina EA, Hubbard NE. Micronutrients and Innate Immunity. J Infect Dis. 2000;182:S5-S10. https://doi.org/10.1086/315922
41. Wang Y, Li J, Wang X, et al. Epigallocatechin-3-Gallate Enhances Hepatitis C Virus Double-Stranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes. Sci Rep. 2016;6:21595. https://doi.org/10.1038/srep21595
42. McKechnie JL, Blish CA. The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19? Cell Host & Microbe. 2020;27(6):863-869. https://doi.org/10.1016/j.chom.2020.05.009
43. Chowdhury P, Barooah AK. Tea Bioactive Modulate Innate Immunity: In Perception to COVID-19 Pandemic. Front Immunol.2020;11:590716. https://doi.org/10.3389/fimmu.2020.590716
44. Bao S, Liu MJ, Lee B, et al. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2010;298(6):L744-754. https://doi.org/10.1152/ajplung.00368.2009
45. Dizdar O, Baspınar O, Kocer D, et al. Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic. Nutrients. 2016;8(3):124. https://doi.org/10.3390/nu8030124
46. Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017;9(12):1286. https://doi.org/10.3390/nu9121286
47. Lee SM, McLaughlin JN, Frederick DR, et al. Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.Am J Physiol Lung Cell Mol Physiol. 2013;304(5):L350-360. https://doi.org/10.1152/ajplung.00243.2012
48. Iddir M, Brito A, Dingeo G, et al. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020;12(6):1562. https://doi.org/10.3390/nu12061562
49. Grant W, Lahore H, McDonnell S, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. https://doi.org/10.3390/nu12040988
50. Mao QQ, Xu XY, Cao SY, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. 019;8(6):185.https://doi.org/10.3390/foods8060185
51. Rodrigues FA, Santos AD, de Medeiros PHQS, et al. Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production. Sci Rep. 2018;8(1):12154. https://doi.org/10.1038/s41598-018-30522-6
52. Idris NA, Yasin HM, Usman A. Voltammetric and spectroscopic determination of polyphenols and antioxidants in ginger(Zingiber officinale Roscoe). Heliyon. 2019;5(5):e01717. https://doi.org/10.1016/j.heliyon.2019.e01717
53. Shariatpanahi ZV, Mokhtari M, Taleban FA, et al. Effect of enteral feeding with ginger extract in acute respiratory distress syndrome. Journal of Critical Care. 2013;28(2):217.e1-217.e6. https://doi.org/10.1016/j.jcrc.2012.04.017
54. Liao YR, Leu YL, Chan YY, et al. Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale. Molecules. 2012;17(8):8928-8937. https://doi.org/10.3390/molecules17088928
55. Klimek-Szczykutowicz, Szopa. Ekiert Citrus limon (Lemon) Phenomenon—A Review of the Chemtry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies. Plants.2020;9(1):119. https://doi.org/10.3390/plants9010119
56. Chambial S, Dwivedi S, Shukla KK, et al. Vitamin C in Disease Prevention and Cure: An Overview. Ind J Clin Biochem.
2013;28(4):314-328. https://doi.org/10.1007/s12291-013-0375-3
57. Hong JY, Lee CY, Lee MG, et al. Effects of dietary antioxidant vitamins on lung functions according to gender and smoking status in Korea: a population-based cross-sectional study. BMJ Open. 2018;8(4):e020656. https://doi.org/10.1136/bmjopen-2017-020656
58. Fisher BJ, Kraskauskas D, Martin EJ, et al. Attenuation of Sepsis-Induced Organ Injury in Mice by Vitamin C. JPEN J Parenter Enteral Nutr. 2014;38(7):825-839. https://doi.org/10.1177/0148607113497760
59. Carr A, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9:1211. https://doi.org/10.3390/nu9111211
60. Rodrigues FA, Santos AD, de Medeiros PHQS, et al. Gingerol suppresses sepsis-induced acute kidney injury by modulatingmethylsulfonylmethane and dimethylamine production. Sci Rep. 2018;8(1):12154. https://doi.org/10.1038/s41598-018-30522-6
61. Jayaprakasha GK, Rao LJM. Chemistry, Biogenesis, and Biological Activities of Cinnamomum zeylanicum. Critical Reviews in Food Science and Nutrition. 2011;51(6):547-562. https://doi.org/10.1080/10408391003699550
62. Rao PV, Gan SH. Cinnamon: A Multifaceted Medicinal Plant. Evidence-Based Complementary and Alternative Medicine. 2014;2014:1-12. https://doi.org/10.1155/2014/642942
63. Zhuang M, Jiang H, Suzuki Y, et al. Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Research. 2009;82(1):73-81. https://doi.org/10.1016/j.antiviral.2009.02.001
64. Simmons G, Bertram S, Glowacka I, et al. Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion. Virology. 2011;413(2):265-274. https://doi.org/10.1016/j.virol.2011.02.020
65. Shahzad A, Cohrs RJ. In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles. Transl Biomed. 2012;3(2):2. https://doi.org/10.3823/434
66. Watanabe K, Rahmasari R, Matsunaga A, et al. Anti-influenza Viral Effects of Honey In Vitro: Potent High Activity of Manuka Honey. Archives of Medical Research. 2014;45(5):359-365. https://doi.org/10.1016/j.arcmed.2014.05.006
67. Chua LS, Abdul-Rahaman NL, Sarmidi MR, et al. Multi-elemental composition and physical properties of honey samples from Malaysia. Food Chemistry. 2012;135(3):880-887. https://doi.org/10.1016/j.foodchem.2012.05.106
68. Dong C, Li X, Song Q, et al. Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19).Infectious Diseases (except HIV/AIDS). 2020.
69. Sulaiman SA, Hasan H, Deris ZZ, et al. The Benefit of Tualang Honey in Reducing Acute Respiratory Symptons Among Malaysian Hajj Pilgrims: A Preliminary Study. J Api Prod Api Med Sci. 2011;3:38-44. https://doi.org/10.3896/IBRA.4.03.1.07
70. Hashem H. In Silico Approach of Some Selected Honey Constituents as SARS-CoV-2 Main Protease (COVID-19) Inhibitors; Chemistry. 2020.
71. Hossain KS, Hossain MG, Moni A, et al. Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises. Heliyon. 2020;6(12):e05798. https://doi.org/10.1016/j.heliyon.2020.e05798
72. Aparicio-Soto M, Sánchez-Hidalgo M, Rosillo MÁ, et al. Extra virgin olive oil: a key functional food for prevention of immuneinflammatory
diseases. Food Funct. 2016;7(11):4492-4505. https://doi.org/10.1039/C6FO01094F
73. Bonura A, Vlah S, Longo A, et al. Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects. Immunobiology. 2016;221(12):1374-1377. https://doi.org/10.1016/j.imbio.2016.07.009
74. Casas R, Estruch R, Sacanella E. The Protective Effects of Extra Virgin Olive Oil on Immune-mediated Inflammatory Responses.EMIDDT. 2017;18(1):23-35. https://doi.org/10.2174/1871530317666171114115632
75. Gambino CM, Accardi G, Aiello A, et al. Effect of Extra Virgin Olive Oil and Table Olives on the ImmuneInflammatory Responses:Potential Clinical Applications. EMIDDT. 2017;18(1):14-22. https://doi.org/10.2174/1871530317666171114113822
76. Majumder D, Debnath M, Sharma KN, et al. Olive oil consumption can prevent non-communicable diseases and COVID-19:Review. CPB. 2022;23(2):261-275. https://doi.org/10.2174/1389201022666210412143553
77. Maideen NMP. Prophetic Medicine-Nigella Sativa (Black cumin seeds) - Potential herb for COVID-19? J Pharmacopuncture.2020;23(2):62-70. https://doi.org/10.3831/KPI.2020.23.010
78. Islam MN, Hossain KS, Sarker PP, et al. Revisiting pharmacological potentials of NIGELLA SATIVA seed: A promising option forCOVID ‐19prevention and cure. Phytotherapy Research 2021;35(3):1329-1344. https://doi.org/10.1002/ptr.6895
79. Bouchentouf S, Missoum N. Identification of Compounds from Nigella Sativa as New Potential Inhibitors of 2019 Novel Coronasvirus (Covid-19): Molecular Docking Study, Chemistry. 2020.
80. Menon VP, Sudheer AR. Antioxidant and Anti-inflammatory Properties of Curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Advances in Experimental Medicine and Biology; Springer US: Boston, MA.
2007;595:105-125.
81. Srivastava RM, Singh S, Dubey SK, et al. Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology. 2011;11:331-341. https://doi.org/10.1016/j.intimp.2010.08.014
82. Avasarala S, Zhang F, Liu G, et al. Curcumin Modulates the Inflammatory Response and Inhibits Subsequent Fibrosis in a Mouse Model of Viral-induced acute respiratory distress syndrome. PLoS ONE. 2013;8(2):e57285. https://doi.org/10.1371/journal. pone.0057285
83. Hosseini A, Rasaie D, Soleymani Asl S, et al. Evaluation of the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure to paraquat in rats. Toxin Reviews. 2019;1-9. https://doi.org/10.1080/15569543.2019.
1675707
84. Chen H, Yang R, Tang Y, et al. Effects of curcumin on pulmonary fibrosis and functions of paraquat-challenged rats. 2017;29(11):973-976. https://doi.org/10.3760/cma.j.issn.2095-4352.2017.11.003
85. Gautam SC, Gao X, Dulchavsky S. Immunomodulation by Curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Springer US: Boston, MA. 2007;595:321-341.
86. WHO monographs on selected medicinal plants; World Health Organization, Ed.; World Health Oganization: Geneva; 1999.
87. Santiago de Chile; Ministerio de Salud MHT: traditional herbal medicines: 103 plant species. 2010.
88. Kuete V. Thymus vulgaris. In Medicinal Spices and Vegetables from Africa; Elsevier. 2017;599609.
89. Salehi B, Abu-Darwish MS, Tarawneh AH, et al. Thymus spp. plants - Food applications and phytopharmacy properties. Trends in Food Science and Technology. 2019;85:287-306. https://doi.org/10.1016/j.tifs.2019.01.020
90. Nolkemper S, Reichling J, Stintzing FC, et al. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta Med. 2006;72(15):1378-1382. https://doi.org/10.1055/s-2006-951719
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Assessment of commitment to healthy daily habits and diets, preventive measures, and beliefs about natural products utilization during COVID-19 pandemic in certain population in Egypt and Saudi Arabia. Pharm Pract (Granada) [Internet]. 2022 Sep. 23 [cited 2025 Jan. 14];20(3):01-16. Available from: https://www.pharmacypractice.org/index.php/pp/article/view/2700
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Assessment of commitment to healthy daily habits and diets, preventive measures, and beliefs about natural products utilization during COVID-19 pandemic in certain population in Egypt and Saudi Arabia. Pharm Pract (Granada) [Internet]. 2022 Sep. 23 [cited 2025 Jan. 14];20(3):01-16. Available from: https://www.pharmacypractice.org/index.php/pp/article/view/2700