Pharmacists’ practices for non-prescribed antibiotic dispensing in Mozambique

Main Article Content

Keywords

Anti-Bacterial Agents, Self Medication, Prescriptions, Pharmacists, Professional Practice, Pharmacies, Drug Resistance, Bacterial, Motivation, Law Enforcement, Public Health, Qualitative Research, Mozambique

Abstract

Background: Antibiotics are the most frequently used medicines worldwide with most of the countries defining these as prescription-only medicines. Though, dispensing non-prescribed antibiotics represent one of the chief causal factors to the irrational use of antibiotics that paves the way to the development of antimicrobial resistance.


Objective: We aimed at describing the practices and the enablers for non-prescribed antibiotic dispensing in Maputo city, Mozambique.


Methods: A qualitative study was conducted, between October 2018 and March 2019, in nine private pharmacies randomly selected across Maputo city. Eighteen pharmacists were contacted and seventeen enrolled through snowball sampling. In-depth interviews were conducted, audiotaped, and transcribed verbatim. Transcripts were coded and analysed though thematic analysis with guidelines from Braun and Clark. The Consolidated Criteria for Reporting Qualitative Studies (COREQ) checklist by (Tong, 2007) was performed.


Results: Out of seventeen, fifteen pharmacists admitted non-prescribed dispensing of antibiotics. Common antibiotic dispensing practices included; dispensing without prescription, without asking for a brief clinical history of patients, without clear explanation of the appropriate way of administering, without advising on the side effects. Reasons for non-prescribed antibiotic dispensing are linked to patients’ behaviour of demanding for non-prescribed antibiotics, to the patients expectations and beliefs on the healing power of antibiotics, to the physicians’ prescribing practices. Other reasons included the pressure for profits from the pharmacy owners, the fragile law enforcement, and absence of accountability mechanisms.


Conclusions: The practices of non-prescribed antibiotic dispensing characterize the ‘daily life’ of the pharmacists. On the one hand, the patient’s demand for antibiotics without valid prescriptions, and pharmacist’s wish to assist based on their role in the pharmacy, the pressure for profits and on the understanding of the larger forces driving the practices of self-medication with antibiotics - rock. On the other hand, pharmacists are aware of the legal status of antibiotics and the public health consequences of their inappropriate dispensing practices and their professional and ethical responsibility for upholding the law - hard place. Highlighting the role of pharmacists and their skills as health promotion professionals is needed to optimizing antibiotic dispensing and better conservancy in Mozambique.

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References

1. Auta A, Hadi MA, Oga E, Adewuyi EO, Abdu-Aguye SN, Adeloye D, Strickland-Hodge B, Morgan DJ. Global access to antibiotics without prescription in community pharmacies: A systematic review and meta-analysis. J Infect. 2019;78(1):8-18. https://doi.org/10.1016/j.jinf.2018.07.001
2. Lipsitch M, Samore MH. Antimicrobial use and antimicrobial resistance: a population perspective [published correction appears in Emerg Infect Dis 2002 May;8(5):540]. Emerg Infect Dis. 2002;8(4):347-354. https://doi.org/10.3201/eid0804.010312
3. Sigaúque B, Sevene E. Situations analysis and recomendations: Antibiotic use and resistance in Mozambique. Available at: https://cddep.org/wp-content/uploads/2017/08/sitan_booklet_a4.pdf (accessed Aug 9, 2020).
4. World Heath Organization, Assessing non-prescription and inappropriate use of antibiotics: report on survey. Geneva: WHO; 2019.
5. Rodrigues CF. Self-medication with antibiotics in Maputo, Mozambique: practices, rationales and relationships. Palgrave Commun. 2020;6(1):1-12. https://doi.org/10.1057/s41599-019-0385-8
6. Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692-701. https://doi.org/10.1016/s1473-3099(11)70054-8
7. Sambakunsi CS, Småbrekke L, Varga CA, Solomon V, Mponda JS. Knowledge, attitudes and practices related to self-medication with antimicrobials in Lilongwe, Malawi. Malawi Med J. 2019;31(4):225-232. https://doi.org/10.4314/mmj.v31i4.2
8. Foster EK, Bandawe CR. How much do patients in Blantyre, Malawi know about antibiotics and other prescription only medicines?. Malawi Med J. 2014;26(1):12-15.
9. World Heath Organization, Antimicrobial Resistance: Global Report on Surveillance. Geneva: WHO; 2014.
10. Mate I, Come CE, Gonçalves MP, Cliff J, Gudo ES. Knowledge, attitudes and practices regarding antibiotic use in Maputo City, Mozambique. PLoS One. 2019;14(8):e0221452. Published 2019 Aug 22. https://doi.org/10.1371/journal.pone.0221452
11. Torres NF, Chibi B, Middleton LE, Solomon VP, Mashamba-Thompson TP. Evidence of factors influencing self-medication with antibiotics in low and middle-income countries: a systematic scoping review. Public Health. 2019;168:92-101. https://doi.org/10.1016/j.puhe.2018.11.018
12. Zajmi D, Berisha M, Begolli I, Hoxha R, Mehmeti R, Mulliqi-Osmani G, Kurti A, Loku A, Raka L. Public knowledge, attitudes and practices regarding antibiotic use in Kosovo. Pharm Pract (Granada). 2017;15(1):827. https://doi.org/10.18549/pharmpract.2017.01.827
13. Al-Kubaisi KA, De Ste Croix M, Vinson D, Sharif SI, Abduelkarem AR. What drives using antibiotic without prescriptions? A qualitative interview study of university students in United Arab Emirates. Pharm Pract (Granada). 2018;16(2):1172. https://doi.org/10.18549/pharmpract.2018.02.1172
14. Jakupi A, Raka D, Kaae S, Sporrong SK. Culture of antibiotic use in Kosovo - an interview study with patients and health professionals. Pharm Pract (Granada). 2019;17(3):1540. https://doi.org/10.18549/pharmpract.2019.3.1540
15. Mansour H, Feghali M, Saleh N, Zeitouny M. Knowledge, practice and attitudes regarding antibiotics use among Lebanese dentists. Pharm Pract (Granada). 2018;16(3):1272. https://doi.org/10.18549/pharmpract.2018.03.1272
16. Bahnassi A. A qualitative analysis of pharmacists' attitudes and practices regarding the sale of antibiotics without prescription in Syria. J Taibah Univ Med Sci, 2015. 10(2):227-233. https://doi.org/10.1016/j.jtumed.2014.09.001
17. Bahnassi A. Pharmacists Views and Practices in Regard to Sales of Antibiotics Without a Prescription in Madinah, Saudi Arabia. J Patient Saf. 2016;12(3):159-164. https://doi.org/10.1097/pts.0000000000000087
18. Ahmad A, Patel I, Mohanta G, Balkrishnan R. Evaluation of self medication practices in rural area of town sahaswan at northern India. Ann Med Health Sci Res. 2014;4(Suppl 2):S73-S78. https://doi.org/10.4103/2141-9248.138012
19. Sawalha AF. A descriptive study of self-medication practices among Palestinian medical and nonmedical university students. Res Social Adm Pharm. 2008;4(2):164-172. https://doi.org/10.1016/j.sapharm.2007.04.004
20. Abdulraheem IS, Adegboye A, Fatiregun AA. Self-medication with antibiotics: empirical evidence from a Nigerian rural population. Br J Pharm Res. 2016;11(5):1-13. https://doi.org/10.9734/BJPR/2016/25268
21. Afolabi AO. Factors influencing the pattern of self-medication in an adult Nigerian population. Ann Afr Med. 2008;7(3):120-127. https://doi.org/10.4103/1596-3519.55666
22. Al-Hamad A. Over-the-counter delivery of antibiotics: are we sending the right message?. Am J Infect Control. 2012;40(1):81-82. https://doi.org/10.1016/j.ajic.2011.08.011
23. Alhomoud F, Aljamea Z, Basalelah L. "Antibiotics kill things very quickly" - consumers' perspectives on non-prescribed antibiotic use in Saudi Arabia. BMC Public Health. 2018;18(1):1177. https://doi.org/10.1186/s12889-018-6088-z
24. Alkhatatbeh MJ, Alefan Q, Alqudah MA. High prevalence of self-medication practices among medical and pharmacy students: a study from Jordan. Int J Clin Pharmacol Ther. 2016;54(5):390-398. https://doi.org/10.5414/cp202451
25. Belkina T, Duvanova N, Karbovskaja J, Tebbens JD, Vlcek J. Antibiotic use practices of pharmacy staff: a cross-sectional study in Saint Petersburg, the Russian Federation. BMC Pharmacol Toxicol. 2017;18(1):11. https://doi.org/10.1186/s40360-017-0116-y
26. Kotwani A, Wattal C, Joshi PC, Holloway K. Irrational use of antibiotics and role of the pharmacist: an insight from a qualitative study in New Delhi, India. J Clin Pharm Ther. 2012;37(3):308-312. https://doi.org/10.1111/j.1365-2710.2011.01293.x
27. Mshana SE, Matee M, Rweyemamu M. Antimicrobial resistance in human and animal pathogens in Zambia, Democratic Republic of Congo, Mozambique and Tanzania: an urgent need of a sustainable surveillance system. Ann Clin Microbiol Antimicrob. 2013;12:28. https://doi.org/10.1186/1476-0711-12-28
28. World Health Organization. The evolving threat of antimicrobial resistance, Options for action. Geneve: WHO; 2012.
29. Kamat VR, Nichter M. Pharmacies, self-medication and pharmaceutical marketing in Bombay, India. Soc Sci Med. 1998;47(6):779-794. https://doi.org/10.1016/s0277-9536(98)00134-8
30. Black E, Cartwright A, Bakharaiba S, Al-Mekaty E, Alsahan D. A qualitative study of pharmacists' perceptions of, and recommendations for improvement of antibiotic use in Qatar. Int J Clin Pharm. 2014;36(4):787-794. https://doi.org/10.1007/s11096-014-9960-7
31. Aponte-González J, González-Acuña A, Lopez J, Brown P, Eslava-Schmalbach J. Perceptions in the community about the use of antibiotics without a prescription: Exploring ideas behind this practice. Pharm Pract (Granada). 2019;17(1):1394. https://doi.org/10.18549/pharmpract.2019.1.1394
32. Aslam A, Gajdács M, Zin CS, Binti Abd Rahman NS, Ahmed SI, Jamshed SQ. Public Awareness and Practices towards Self-Medication with Antibiotics among the Malaysian Population. A Development of Questionnaire and Pilot-Testing. Antibiotics (Basel). 2020;9(2):97. https://doi.org/10.3390/antibiotics9020097
33. Berzanskyte A, Valinteliene R, Haaijer-Ruskamp FM, Gurevicius R, Grigoryan L. Self-medication with antibiotics in Lithuania. Int J Occup Med Environ Health. 2006;19(4):246-253. https://doi.org/10.2478/v10001-006-0030-9
34. Bilal M, Haseeb A, Khan MH, Arshad MH, Ladak AA, Niazi SK, Musharraf MD, Manji AA. Self-Medication with Antibiotics among People Dwelling in Rural Areas of Sindh. J Clin Diagn Res. 2016;10(5):OC08-OC13. https://doi.org/10.7860/jcdr/2016/18294.7730
35. Brata C, Fisher C, Marjadi B, Schneider CR, Clifford RM. Factors influencing the current practice of self-medication consultations in Eastern Indonesian community pharmacies: a qualitative study. BMC Health Serv Res. 2016;16:179. Published 2016 May 13. https://doi.org/10.1186/s12913-016-1425-3
36. Elong Ekambi GA, Okalla Ebongue C, Penda IC, Nnanga Nga E, Mpondo Mpondo E, Eboumbou Moukoko CE. Knowledge, practices and attitudes on antibiotics use in Cameroon: Self-medication and prescription survey among children, adolescents and adults in private pharmacies. PLoS One. 2019;14(2):e0212875. https://doi.org/10.1371/journal.pone.0212875
37. Emeka PM, Al-Omar MJ, Khan TM. A qualitative study exploring role of community pharmacy in the irrational use and purchase of nonprescription antibiotics in Al Ahsa. Eur J Gen Med. 2012;9(4):230-234. https://doi.org/10.29333/ejgm/82436
38. Gajdács M, Paulik E, Szabó A. Knowledge, Attitude and Practice of Community Pharmacists Regarding Antibiotic Use and Infectious Diseases: A Cross-Sectional Survey in Hungary (KAPPhA-HU). Antibiotics (Basel). 2020;9(2):41. https://doi.org/10.3390/antibiotics9020041
39. Grigoryan L, Germanos G, Zoorob R, Juneja S, Raphael JL, Paasche-Orlow MK, Trautner BW. Use of Antibiotics Without a Prescription in the U.S. Population: A Scoping Review. Ann Intern Med. 2019;171(4):257-263. https://doi.org/10.7326/m19-0505
40. Hadi MA, Karami NA, Al-Muwalid AS, Al-Otabi A, Al-Subahi E, Bamomen A, Mohamed MM, Elrggal ME. Community pharmacists' knowledge, attitude, and practices towards dispensing antibiotics without prescription (DAwP): a cross-sectional survey in Makkah Province, Saudi Arabia. Int J Infect Dis. 2016;47:95-100. https://doi.org/10.1016/j.ijid.2016.06.003
41. Heidarifar R, Koohbor M, Kazemian Mansourabad M, Mikaili P, Sarahroodi S. Selfmedication with Antibiotics among Iranian Population in Qom State. J Sci Innov Res. 2013;2(4):785-789.
42. Horumpende PG, Sonda TB, van Zwetselaar M, Antony ML, Tenu FF, Mwanziva CE, Shao ER, Mshana SE, Mmbaga BT, Chilongola JO. Prescription and non-prescription antibiotic dispensing practices in part I and part II pharmacies in Moshi Municipality, Kilimanjaro Region in Tanzania: A simulated clients approach. PLoS One. 2018;13(11):e0207465. https://doi.org/10.1371/journal.pone.0207465
43. Israel EU, Emmanuel EG, Sylvester EG, Chukum E. Self-medication with antibiotics amongst civil servants in Uyo, Southern Nigeria. J Adv Med Pharm Sci. 2015;2(3):89-97. https://doi.org/10.9734/JAMPS/2015/15147
44. Khan RA. Self-medication with antibiotics: Practices among Pakistani students in Sweden and Finland. Available at: http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A452461 (accessed May 9, 2020).
45. Llor C, Cots JM. Dispensing of antibiotics without a medical prescription and communication skills of pharmacists. Aten Primaria. 2013;45(9):496-497. https://doi.org/10.1016/j.aprim.2013.02.004
46. Ngigi, C.K., P. Mwagiru, and J. Wala, Self-Medication with antibiotics prior to seeking treatment among adult patients attending outpatient department at Gatundu Sub-County Hospital, Kiambu county, Kenya. Imp J Interdiscip Res. 2016;2(8):609-616.
47. Torres NF, Solomon VP, Middleton LE. Patterns of self-medication with antibiotics in Maputo City: a qualitative study. Antimicrob Resist Infect Control. 2019;8:161. https://doi.org/10.1186/s13756-019-0618-z
48. Miller R, Goodman C. Performance of retail pharmacies in low- and middle-income Asian settings: a systematic review. Health Policy Plan. 2016;31(7):940-953. https://doi.org/10.1093/heapol/czw007
49. Shet A, Sundaresan S, Forsberg BC. Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector. Antimicrob Resist Infect Control. 2015;4:55. https://doi.org/10.1186/s13756-015-0098-8
50. The Center For Disease Dynamics, Economics & Policy. Situations Analysis and recomendations: Antibiotic Use and Resistance in Mozambique. Available at: https://cddep.org/wp-content/uploads/2017/06/moz_sitan_4_page_brochure_b_1-1.pdf (accessed May 9, 2020).
51. Centro de Integridade Pública. A falta de medicamentos está também associada a precariedade no funcionamento da logística farmacêutica no sistema público de saúde. Maputo: CIP; 2015.
52. Município de Maputo. [Informal drug sales in Maputo city, causes and consequences for publis health]. Available at: https://www.medicusmundimozambique.org/files/2018/02/Venta_Med_Maputo.pdf (accessed May 9, 2020).
53. Zahreddine L, Hallit S, Shakaroun S, Al-Hajje A, Awada S, Lahoud N. Knowledge of pharmacists and parents towards antibiotic use in pediatrics: a cross-sectional study in Lebanon. Pharm Pract (Granada). 2018;16(3):1194. https://doi.org/10.18549/pharmpract.2018.03.1194
54. Sapkota AR, Coker ME, Rosenberg Goldstein RE, Atkinson NL, Sweet SJ, Sopeju PO, Ojo MT, Otivhia E, Ayepola OO, Olajuyigbe OO, Shireman L, Pottinger PS, Ojo KK. Self-medication with antibiotics for the treatment of menstrual symptoms in Southwest Nigeria: a cross-sectional study. BMC Public Health. 2010;10:610. https://doi.org/10.1186/1471-2458-10-610
55. Widayati A, Suryawati S, de Crespigny C, Hiller JE. Self medication with antibiotics in Yogyakarta City Indonesia: a cross sectional population-based survey. BMC Res Notes. 2011;4:491. https://doi.org/10.1186/1756-0500-4-491
56. Kalungia AC, Burger J, Godman B, Costa JO, Simuwelu C. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Expert Rev Anti Infect Ther. 2016;14(12):1215-1223. https://doi.org/10.1080/14787210.2016.1227702
57. Ministerio Da Saúde. [Cirriculum of Pharmacy Technicians]. Moçambique: MdS; 2007.
58. Clarke V. Braun V. Teaching thematic analysis: Overcoming challenges and developing strategies for effective learning. Psychologist. 2013;26(2):120-123.
59. Braun V, Clarke V, Hayfield N, Terry G. Thematic Analysis. In: Liamputtong P, ed. Handbook of Research Methods in Health Social Sciences. Singapore: Springer; 2019.
60. Braun V, Clarke V, Thematic analysis. In: Cooper H, Camic PM, Long DL, Panter AT, Rindskopf D, Sher KJ, eds. APA handbooks in psychology. APA: Washington, DC; 2012.
61. Nowell LS, , Norris JM, White DE, Moules NJ. Thematic analysis: Striving to meet the trustworthiness criteria. Int J Qual Methods. 2017;16(1):1609406917733847. https://doi.org/10.1177/1609406917733847
62. Hawkey PM, Jones AM. The changing epidemiology of resistance. J Antimicrob Chemother. 2009;64(suppl 1):i3-i10.
63. Gebretekle GB, Serbessa MK. Exploration of over the counter sales of antibiotics in community pharmacies of Addis Ababa, Ethiopia: pharmacy professionals' perspective. Antimicrob Resist Infect Control. 2016;5:2. https://doi.org/10.1186/s13756-016-0101-z
64. Yakimova Y. Pharmacists' knowledge of the safety of antibiotics for systemic use. Int J Risk Saf Med. 2015;27(Suppl 1):S11-S12. https://doi.org/10.3233/jrs-150670
65. Fang Y, Yang S, Zhou S, Jiang M, Liu J. Community pharmacy practice in China: past, present and future. Int J Clin Pharm. 2013;35(4):520-528. https://doi.org/10.1007/s11096-013-9789-5
66. Azhar S, Hassali MA, Ibrahim MI, Ahmad M, Masood I, Shafie AA. The role of pharmacists in developing countries: the current scenario in Pakistan. Hum Resour Health. 2009;7:54. https://doi.org/10.1186/1478-4491-7-54
67. Parthasarathi G, Ramesh M, Nyfort-Hansen K, Nagavi BG. Clinical pharmacy in a South Indian teaching hospital. Ann Pharmacother. 2002;36(5):927-932. https://doi.org/10.1345/aph.1a223
68. Basak SC, van Mil JW, Sathyanarayana D. The changing roles of pharmacists in community pharmacies: perception of reality in India. Pharm World Sci. 2009;31(6):612-618. https://doi.org/10.1007/s11096-009-9307-y
69. Magedanz L, Silliprandi EM, dos Santos RP. Impact of the pharmacist on a multidisciplinary team in an antimicrobial stewardship program: a quasi-experimental study. Int J Clin Pharm. 2012;34(2):290-294. https://doi.org/10.1007/s11096-012-9621-7
70. Sakeena MHF, Bennett AA, McLachlan AJ. Enhancing pharmacists' role in developing countries to overcome the challenge of antimicrobial resistance: a narrative review. Antimicrob Resist Infect Control. 2018;7:63. https://doi.org/10.1186/s13756-018-0351-z
71. Brink AJ, Messina AP, Feldman C, Richards GA, Becker PJ, Goff DA, Bauer KA, Nathwani D, van den Bergh D; Netcare Antimicrobial Stewardship Study Alliance. Antimicrobial stewardship across 47 South African hospitals: an implementation study. Lancet Infect Dis. 2016;16(9):1017-1025. https://doi.org/10.1016/s1473-3099(16)30012-3
72. Norris P, Chamberlain K, Dew K, Gabe J, Hodgetts D, Madden H. Public Beliefs about Antibiotics, Infection and Resistance: A Qualitative Study. Antibiotics (Basel). 2013;2(4):465-476. https://doi.org/10.3390/antibiotics2040465
73. Napolitano F, Izzo MT, Di Giuseppe G, Angelillo IF. Public knowledge, attitudes, and experience regarding the use of antibiotics in Italy. PLoS One. 2013;8(12):e84177. https://doi.org/10.1371/journal.pone.0084177
74. Pavydė E, Veikutis V, Mačiulienė A, Mačiulis V, Petrikonis K, Stankevičius E. Public Knowledge, Beliefs and Behavior on Antibiotic Use and Self-Medication in Lithuania. Int J Environ Res Public Health. 2015;12(6):7002-7016. Published 2015 Jun 17. https://doi.org/10.3390/ijerph120607002
75. Anghel IB, Craciun C. Self-Medication with over-the-counter drugs and antibiotics in Romanian consumers: A qualitative study. Cogn Brain Behav. 2013;17(3):215-235.
76. Mamade S, Suleman F, Smabrekke L. Antibiotic prescription patterns for outpatients at a Central Hospital in Maputo city, Mozambique [Masters Dissertation], School of Pharmaceutical Sciences, University of KwaZulu Natral, 2019.
77. Yates TD, Davis ME, Taylor YJ, Davidson L, Connor CD, Buehler K, Spencer MD. Not a magic pill: a qualitative exploration of provider perspectives on antibiotic prescribing in the outpatient setting. BMC Fam Pract. 2018;19(1):96. Published 2018 Jun 23. https://doi.org/10.1186/s12875-018-0788-4
78. Yaacoub SG, Koyess V, Lahoud N, Rahme D, Francis N, Saleh N, Maison P. Antibiotic prescribing for acute uncomplicated cystitis in Lebanese community pharmacies using a simulated patient. Pharm Pract (Granada). 2019;17(4):1604. https://doi.org/10.18549/pharmpract.2019.4.1604
79. van der Geest S, Whyte SR. The charm of medicines: metaphors and metonyms. Med Anthropol Q. 1989;3(4):345-367.
80. Chalker J, Ratanawijitrasin S, Chuc NT, Petzold M, Tomson G. Effectiveness of a multi-component intervention on dispensing practices at private pharmacies in Vietnam and Thailand--a randomized controlled trial. Soc Sci Med. 2005;60(1):131-141. https://doi.org/10.1016/j.socscimed.2004.04.019
81. Finch RG, Metlay JP, Davey PG, Baker LJ; International Forum on Antibiotic Resistance colloquium. Educational interventions to improve antibiotic use in the community: report from the International Forum on Antibiotic Resistance (IFAR) colloquium, 2002. Lancet Infect Dis. 2004;4(1):44-53. https://doi.org/10.1016/s1473-3099(03)00860-0
82. Kozman D, Schuttner L, Chunda L, Tymchuk C. Educational intervention to improve antibiotic knowledge at Kamuzu Central Hospital, Malawi. Lancet Glob Health, 2018;6(special):S43. https://doi.org/10.1016/S2214-109X(18)30172-4